Multiple primary lung carcinomas |
---|
Same histology, anatomically separated |
Carcinomas in different lobes |
And no N2,3 involvement |
And no systemic metastases |
Same histology, temporally separated |
≥ 4-yr interval between carcinomas |
And no systemic metastases from either carcinoma |
Different histology |
Different histology type |
Or different molecular genetic characteristics |
Or arising separately from foci of carcinoma in situ |