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Table 1 The criteria to diagnose multiple primary lung carcinoma according to ACCP

From: The CT delta-radiomics based machine learning approach in evaluating multiple primary lung adenocarcinoma

Multiple primary lung carcinomas

Same histology, anatomically separated

 Carcinomas in different lobes

 And no N2,3 involvement

 And no systemic metastases

Same histology, temporally separated

  ≥ 4-yr interval between carcinomas

 And no systemic metastases from either carcinoma

Different histology

 Different histology type

 Or different molecular genetic characteristics

 Or arising separately from foci of carcinoma in situ