Table 3 Univariate and multivariate analysis of the risk factors in EBC^* with ALNM

Age

0.134

1.150 (0.958, 1.380)

Histologic type

 IDC

Ref

 Lobular

0.816

1.124(0.420,3.099)

 Other

0.132

0.201(0.025,1.619)

Ki-67

 < 0.0001

6.461 (3.976, 10.522)

0.007

3.568(1.419,8.971)

P53

0.657

1.096(0.732, 1.640)

ER

0.052

0.627(0.392,1.004)

PR

0.147

0.733(0.482,1.115)

HER-2

0.001

2.121(1.379,3.264)

0.100

1.701(0.904,3.202)

MS

 TN

Ref

 Lumina A

 < 0.001

0.201(0.091, 0.445)

0.535

0.671(0.190,2.367)

 Lumina B

0.679

1.157(0.579, 2.315)

0.516

1.310(0.581,2.953)

 Her-2 overexpression

0.783

0.882(0.362, 2.148)

0.241

0.496(0.154,1.601)

Location

 Inner lower quadrant

Ref

 Upper outer quadrant

0.078

2.342(0.909, 6.035)

 Outer lower quadrant

0.426

1.522(0.541, 4.283)

 Upper inner quadrant

0.559

1.366(0.480, 3.885)

 Distance to nipple

0.435

0.963(0.876, 1.059)

 Distance to skin

0.159

0.710(0.441, 1.144)

 MD

 < 0.001

1.876(1.504, 2.340)

 < 0.0001

1.673(1.289,2.171)

Margin

 Circumscribe

Ref

 Spiculated

0.413

1.316(0.682, 2.541)

 Angular

0.140

1.760(0.830, 3.371)

 Indistinct

0.066

1.964(0.956, 4.033)

 Shape

0.006

5.482(1.631, 18.434)

0.306

2.034(0.522,7.921)

Internal echo pattern

 Hypoechoic

Ref

 Heterogeneous / complex cystic and solid

0.023

0.238(0.069, 0.817)

0.056

0.260(0.065,1.036)

 Iso- / hyperechoic

0.095

0.274(0.060, 1.253)

0.623

0.667(0.132,3.355)

Calcifications

 No

Ref

Ref

 Micro

0.008

1.681(1.146, 2.465)

0.381

1.238(0.768,1.995)

 Macro

0.719

1.307(0.304, 5.631)

0.860

0.845(0.129,5.525)

 Orientation

0.840

1.072(0.544, 2.114)

Posterior features

 No posterior features

Ref

Ref

 Shadowing

 < 0.001

4.204(2.489, 7.100)

 < 0.001

4.446(2.395,8.256)

 Enhancement

0.004

2.156(1.285, 3.616)

0.019

2.156(1.135,4.098)

 Combined pattern

0.609

1.601(0.263, 9.743)

0.986

1.018(0.137,4.098)

 Hyperechoic halo

 < 0.0001

2.262(1.506, 3.397)

0.004

2.033(1.254,3.294)

 Retraction phenomenon in coronal view

0.208

1.285(0.869, 1.899)