Table 4 Bivariate analysis of associations between sample characteristics and treatment plan changes

Age (years old)

X² (1, N = 97) = 1.10

.29

X² (1, N = 97) = 0.26

.60

 < 65 years old

7 (43.8%)

47 (58.0%)

15 (51.7%)

39 (57.4%)

 \(\ge 65\) years old

9 (56.3%)

34 (42.0%)

14 (48.3%)

29 (42.6%)

Gender

2-tailed Fisher’s exact

.006

X² (1, N = 97) = 1.38

.24

 Female

13 (81.3%)

35 (43.2%)

17 (58.6%)

31 (45.6%)

 Male

3 (18.8%)

46 (56.8%)

12 (41.4%)

37 (54.4%)

Race

2-tailed Fisher’s exact

.45

2-tailed Fisher’s exact

1.00

 White

15 (93.8%)

68 (84.0%)

25 (86.2%)

58 (85.3%)

 Non-White

1 (6.3%)

13 (16.0%)

4 (13.8%)

10 (14.7%)

Types of Cancer

2-tailed Fisher’s exact

.006

2-tailed Fisher’s exact

.44

 Breast

6 (37.5%)

9 (11.1%)

3 (10.3%)

12 (17.5%)

 Colorectal

5 (31.3%)

13 (16.0%)

6 (20.7%)

12 (17.5%)

 Pancreatic

2 (12.5%)

38 (46.9%)

15 (51.7%)

25 (36.8%)

 Others

3 (18.8%)

21 (25.9%)

5 (17.2%)

19 (27.9%)

Stage of Cancer

X² (1, N = 97) = 0.11

.74

X² (1, N = 97) = 0.0003

.98

 Non-advanced/metastatic

6 (37.5%)

34 (42.0%)

12 (41.4%)

28 (41.2%)

 Advanced/metastatic

10 (62.5%)

47 (58.0%)

17 (58.6%)

40 (58.8%)

Treatment type

X² (1, N = 97) = 4.16

.04

X² (1, N = 97) = 0.03

.85

 Monotherapy

8 (50.0%)

20 (24.7%)

8 (27.6%)

20 (29.4%)

 Combination therapy

8 (50.0%)

61 (75.3%)

21 (72.4%)

48 (70.6%)

Capecitabine daily dose (mg) (Mean ± SD)

2906.25 ± 1128.70

2370.00 ± 1021.34

U = 464.5

.07

2051.72 ± 1175.23

2635.82 ± 951.67

U = 619

.003

Days on treatment (days) (Mean ± SD)

76 ± 150.49

44.58 ± 53.47

U = 539

.28

53.69 ± 104.92

48.09 ± 63.80

U = 940

.28

Cycle pattern

2-tailed Fisher’s exact

.40

X² (1, N = 97) = 1.29

.25

 14 days on, 7 days off

12 (75.0%)

50 (61.7%)

21 (39.7%)

41 (60.3%)

 Others

4 (25.0%)

31 (38.3%)

8 (27.6%)

27 (39.7%)

Number of comorbidities (Mean ± SD)

4.44 ± 2.45

3.79 ± 2.28

U = 529

.23

4.24 ± 2.23

3.75 ± 2.35

U = 833

.22

Number of outpatient medications (Mean ± SD)

8.88 ± 5.52

10.40 ± 5.12

t (95) = 1.07

.28

10.45 ± 5.34

10.01 ± 5.16

t (95) = -0.37

.70

Nausea (severity) (Mean ± SD)

0.62 ± 0.72

0.69 ± 0.97

U = 633

.87

0.76 ± 1.06

0.65 ± 0.88

U = 932.5

.63

Vomiting (severity) (Mean ± SD)

0.19 ± 0.40

0.32 ± 0.79

U = 634

.84

0.48 ± 1.09

0.22 ± 0.51

U = 947.5

.66

Diarrhea (severity) (Mean ± SD)

0.67 ± 0.90

0.85 ± 1.07

U = 565

.64

1.07 ± 1.18

0.72 ± 0.97

U = 796.5

.17

Hand Foot Syndrome (severity) (Mean ± SD)

1.12 ± 1.26

0.41 ± 0.82

U = 424.5

.007

0.79 ± 1.24

0.41 ± 0.76

U = 848.5

.17

Fatigue (severity) (Mean ± SD)

1.00 ± 1.03

1.16 ± 0.99

U = 583

.50

1.34 ± 1.01

1.04 ± 0.98

U = 818.5

.16

Constipation (severity) (Mean ± SD)

0.44 ± 0.89

0.69 ± 1.07

U = 566.5

.35

0.59 ± 1.21

0.68 ± 0.97

U = 864

.25

Mouth sores (severity) (Mean ± SD)

0.44 ± 0.89

0.27 ± 0.65

U = 600.5

.50

0.41 ± 0.91

0.25 ± 0.58

U = 952.5

.70

Sleep difficulties (severity) (Mean ± SD)

0.19 ± 0.54

0.42 ± 0.76

U = 546.5

.19

0.38 ± 0.78

0.38 ± 0.71

U = 967.5

.84