Table 7 Bryne’s Tumor Invasive Front (TIF) Grading System [36]
Morphological feature | SCORE | |||
|---|---|---|---|---|
1 | 2 | 3 | 4 | |
Degree of keratinization | Highly keratinized (> 50% of the cells) | Moderately keratinized (20- 50% of the cells) | Minimal keratinization (5-20% of the cells) | No keratinization (0-50/, of the cells) |
Nuclear polymorphism | Little nuclear polymorphism (> 75% mature cells) | Moderately abundant nuclear polymorphism (50-75% mature cells) | Abundant nuclear polymorphism (25- 50% mature cells) | Extreme nuclear polymorphism (0- 25% mature cells) |
Number of mitoses (high power field)* | 0-1 | 2-3 | 4-5 | > 5 |
Pattern of invasion | Pushing, well delineated infiltrating borders | Infiltrating, solid cords, bands and/ or strands | Small groups or cords of infiltrating cells (n > 15) | Marked and widespread cellular dissociation in small groups and/ or in single cells (n < 15) |
Lymphoplasmacytic infiltrate | Marked | Moderate | Slight | None |