Skip to main content

Table 7 Bryne’s Tumor Invasive Front (TIF) Grading System [36]

From: Expressional variations of Kaiso: an association with pathological characteristics and field cancerization of OSCC

Morphological feature SCORE
1 2 3 4
Degree of keratinization Highly keratinized (> 50% of the cells) Moderately keratinized (20- 50% of the cells) Minimal keratinization (5-20% of the cells) No keratinization (0-50/, of the cells)
Nuclear polymorphism Little nuclear polymorphism (> 75% mature cells) Moderately abundant nuclear polymorphism (50-75% mature cells) Abundant nuclear polymorphism (25- 50% mature cells) Extreme nuclear polymorphism (0- 25% mature cells)
Number of mitoses (high power field)* 0-1 2-3 4-5 > 5
Pattern of invasion Pushing, well delineated infiltrating borders Infiltrating, solid cords, bands and/ or strands Small groups or cords of infiltrating cells (n > 15) Marked and widespread cellular dissociation in small groups and/ or in single cells (n < 15)
Lymphoplasmacytic infiltrate Marked Moderate Slight None