Fig. 6
From: Lentinan enhances the antitumor effects of Delta-like 1 via neutrophils
The improved antitumor effects of LNT in LAP-L1 lung cancers were dependent on intratumoral CD11b+Gr1hi neutrophils. a Experimental design: FVB mice were s.c. inoculated with 2 × 105 LAP-L1 lung cancer cells on the right flank. When tumors reached 5 × 6 mm in diameter, mice were randomly divided into 4 groups and received i.p. injection of NS (saline), LNT (1.0 mg/kg), anti-Gr1 antibody (200 μg/mouse) or LNT plus anti-Gr1 antibody for 9 days; b Tumor growth curves were recorded and tumor weight was measured at the end of the treatments; c The proportions of TAMs; d The proportions of intratumoral Gr1hiCD11b+ (CD11b+Ly6G+) neutrophils. All data in this report are presented as means ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001