Table 1 Clinicopathological characteristics of the entire VSCC cohort, HPV-independent cohort, and HPV-dependent sub-cohorts. No HPV status was available for 24 patients. SD = standard deviation
Clinicopathological parameters | All (N = 126) | HPV-independent (N = 79) | HPV-dependent (N = 23) |
|---|---|---|---|
Age (years) | |||
Mean (± SD) | 64.1 ± 14.4 | 65.1 ± 14.0 | 57.5 ± 15.2 |
Min–max | 25—93 | 33—93 | 25—84 |
Overall survival (months) | |||
Mean (± SD) | 54.0 ± 42 | 58.8 ± 44.7 | 53.7 ± 39.5 |
Median | 46.0 | 58.0 | 48.0 |
TNM classification | |||
T1 | 102 (81.0%) | 65 (82.3%) | 16 (69.6%) |
T2 | 17 (13.5%) | 12 (15.2%) | 4 (17.4%) |
T3 | 3 (2.4%) | 1 (1.3%) | 2 (8.7%) |
Tx | 4 (3.2%) | 1 (1.3%) | 1 (4.3%) |
N0 | 48 (38.1%) | 33 (41.8%) | 4 (17.4%) |
N1 | 10 (7.9%) | 6 (7.6%) | 4 (17.4%) |
N2 | 21 (16.7%) | 16 (20.3%) | 4 (17.4%) |
N3 | 1 (0.8%) | 0 | 0 |
Nx | 46 (36.5%) | 24 (30.4%) | 11 (47.8%) |
Grading | |||
G1 | 11 (8.7%) | 5 (6.3%) | 2 (8.7%) |
G2 | 82 (65.1%) | 52 (65.8%) | 16 (69.6%) |
G3 | 29 (23.0%) | 19 (24.1%) | 4 (17.4%) |
not determined | 4 (3.2%) | 3 (3.8%) | 1 (4.3%) |
HPV-subtypes | |||
16 | 18 (76%) | ||
33 | 3 (12%) | ||
33 + 16 | 3 (12%) | ||