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Table 3 Univariable and multivariable analysis of parameters for overall survival

From: AST·MLR index and operation injury condition are novel prognostic predictor for the prediction of survival in patients with colorectal cancer liver metastases undergoing surgical resection

Parameters

Univariable analysis

Multivariable analysis

 

HR

95% CI

P value

HR

95% CI

P value

Age ≥ 60 years

1.028

0.749—1.412

0.863

   

Female

0.872

0.637—1.194

0.394

   

BMI ≥ 24 kg/m2

0.981

0.721—1.333

0.901

   

ASA score 1–2

1.212

0.766—1.917

0.412

   

Primary site colon

1.186

0.870—1.618

0.281

   

Right hemicolon

1.162

0.778—1.736

0.464

   

R0 resectiona

0.506

0.368—0.694

< 0.001*

0.635

0.455—0.887

0.008*

Poorly differentiated

1.087

0.758—1.559

0.649

   

T3-T4

1.182

0.656—2.128

0.578

   

N1-N2a

1.798

1.231—2.626

0.002*

1.512

1.027—2.225

0.036*

Synchronous metastasis

1.388

0.929—2.075

0.109

   

Extrahepatic metastasesa

1.804

1.176—2.768

0.007*

1.705

1.100—2.641

0.017*

Diameter of metastases > 5 cm

0.925

0.560—1.529

0.762

   

Multiple metastasesa

1.814

1.316—2.501

< 0.001*

  

0.221

Bilobar distributiona

1.899

1.386—2.602

< 0.001*

  

0.663

Preoperative CEA > 50 ng/mla

1.703

1.190—2.437

0.004*

1.500

1.039—2.166

0.030*

Major liver resectiona

2.159

1.582—2.948

< 0.001*

1.353

0.962—1.903

0.082**

Hepatectomy only

0.969

0.701—1.339

0.848

   

Radio frequency ablationa

1.523

0.986—2.354

0.058

  

0.764

Preoperative chemotherapya

1.630

1.177—2.258

0.003*

  

0.856

Postoperative chemotherapya

0.605

0.444—0.825

0.001*

0.591

0.432—0.809

0.001*

Comorbidity

0.907

0.664—1.240

0.542

   

Postoperative complicationa

1.832

1.343—2.498

< 0.001*

1.552

1.125—2.142

0.007*

Postoperative major complication

1.218

0.810—1.833

0.344

   

Serious operation injury conditiona

2.072

1.520—2.824

< 0.001*

1.539

1.101—2.151

0.012*

AMLRI > 3.33a

2.295

1.430—3.684

0.001*

2.162

1.334—3.503

0.002*

AST > 14 U/L

1.948

1.082—3.508

0.026*

   

MLR > 0.15

1.618

0.982—2.667

0.059

   

Blood loss (ml)

1.969

1.399—2.771

< 0.001*

   

Operation time (min)

1.596

1.170—2.177

< 0.001*

   

CRS 3–5

1.788

1.312—2.436

< 0.001*

   
  1. BMI body mass index, ASA American Society of Anesthesiologists T tumour staging, N lymph node staging, CEA carcinoembryonic antigen, CRS clinical risk score, AMLRI AST·MLR index, AST aspartate aminotransferase, MLR monocyte-to-lymphocyte ratio
  2. aIncluded in multivariable analysis
  3. *Statistically significant
  4. **0.05 < p < 0.10, included automatically by the forward stepwise (conditional LR) method of Cox regression