Characteristics | Number of patients (%) | Unadjusted HR (95% CI) | P Value | Adjusted HR (95% CI) | P Value | |
---|---|---|---|---|---|---|
Total | 13,614 (100.0) | |||||
Age, years | < 30 | 53 (0.4) | 1 | 1 | ||
30–39 | 447 (3.3) | 0.71 (0.41–1.21) | 0.207 | 0.69 (0.40–1.18) | 0.172 | |
40–49 | 1,417 (10.4) | 0.54 (0.32–0.91) | 0.021 | 0.53 (0.31–0.89) | 0.016 | |
50–59 | 2,980 (21.9) | 0.61 (0.36–1.01) | 0.057 | 0.57 (0.34–0.95) | 0.032 | |
60–69 | 3,759 (27.6) | 0.76 (0.46–1.27) | 0.294 | 0.70 (0.42–1.17) | 0.173 | |
70–79 | 4,166 (30.6) | 1.18 (0.71–1.96) | 0.528 | 0.95 (0.57–1.58) | 0.834 | |
≥ 80 | 792 (5.8) | 2.10 (1.25–3.53) | 0.005 | 1.44 (0.85–2.43) | 0.175 | |
Gender | Male | 9,226 (67.8) | 1 | 1 | ||
Female | 4,388 (32.2) | 0.86 (0.80–0.93) | 0.0002 | 0.83 (0.77–0.90) | < 0.0001 | |
Comorbidities | ||||||
DM | No | 10,254 (75.3) | 1 | 1 | ||
Yes | 3,360 (24.7) | 1.25 (1.16–1.36) | < 0.0001 | 1.11 (1.01–1.21) | 0.03 | |
Hypertension | No | 7,811 (57.4) | 1 | 1 | ||
Yes | 5,803 (42.6) | 1.16 (1.08–1.25) | < 0.0001 | 0.89 (0.82–0.96) | 0.004 | |
Dyslipidemia | No | 9,079 (66.7) | 1 | 1 | ||
Yes | 4,535 (33.3) | 1.04 (0.97–1.13) | 0.292 | 0.96 (0.88–1.05) | 0.375 | |
COPD | No | 12,053 (88.5) | 1 | 1 | ||
Yes | 1,561 (11.5) | 1.19 (1.07–1.33) | 0.002 | 0.99 (0.89–1.10) | 0.839 | |
Chemotherapy cycles | ≥ 8 cycles | 6,930 (50.9) | 1 | 1 | ||
7 < cycles < 8 | 1,071 (7.9) | 1.60 (1.39–1.84) | < 0.0001 | 1.54 (1.34–1.78) | < 0.0001 | |
6 < cycles ≤ 7 | 990 (7.3) | 2.11 (1.84–2.41) | < 0.0001 | 2.03 (1.78–2.32) | < 0.0001 | |
5 < cycles ≤ 6 | 709 (5.2) | 3.08 (2.65–3.57) | < 0.0001 | 2.86 (2.47–3.32) | < 0.0001 | |
≤ 5 cycles | 3,914 (28.7) | 4.06 (3.74–4.40) | < 0.0001 | 3.64 (3.35–3.95) | < 0.0001 |