| Overall Survival | Progression-free Survival | ||
---|---|---|---|---|
Variable | HR (95%CI) | P value | HR (95%CI) | P value |
Gender | Â | Â | Â | 0.096 |
 Male | 1[Reference] | 0.999 | 1[Reference] |  |
 Female | 1.00(0.56–2.02) |  | 0.60(0.33–1.10) |  |
Age (years) | Â | 0.858 | Â | 0.395 |
  < 65 | 1[Reference] |  | 1[Reference] |  |
  ≥ 65 | 1.06(0.56–2.02) |  | 0.76(0.40–1.44) |  |
ECOG PS | Â | 0.001* | Â | 0.003* |
 0–1 | 1[Reference] |  | 1[Reference] |  |
  ≥ 2 | 3.49(1.64–7.44) |  | 2.82(1.43–5.58) |  |
Primary tumor site | Â | 0.885 | Â | 0.628 |
 Gastro-esophageal unction | 1[Reference] |  | 1[Reference] |  |
 Stomach | 0.95(0.47–1.94) |  | 0.86(0.46–1.61) |  |
Stage | Â | 0.129 | Â | 0.134 |
 III | 1[Reference] |  | 1[Reference] |  |
 IV | 2.05(0.81–5.16) |  | 1.90(0.82–4.37) |  |
Lines of immunotherapy | Â | 0.040* | Â | 0.012* |
  < 2 | 1[Reference] |  | 1[Reference] |  |
  ≥ 2 | 2.00(1.03–3.90) |  | 2.22(1.19–4.12) |  |
Combined with other therapies | Â | 0.041* | Â | 0.148 |
 No | 1[Reference] |  | 1[Reference] |  |
 Yes | 0.55(0.31–0.98) |  | 0.69(0.41–1.14) |  |
H. pylori status | Â | 0.052 | Â | 0.022* |
 Negative | 1[Reference] |  | 1[Reference] |  |
 Positive | 1.76(0.99–3.12) |  | 1.90(1.10–3.30) |  |