Fig. 3From: Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expressionActive form of NOTCH1 following GSI treatment. NOTCH1 polypeptides were immunoprecipitated from whole-cell extracts using antibodies against GS-cleaved active NOTCH1 (ab8925). TM/RAM species (ICN1) were lost after incubation with GSI. Brackets show aberrant accumulation of TM/RAM species (ICN1) of HD-Mar with NOTCH1 rearrangementBack to article page