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Fig. 6 | BMC Cancer

Fig. 6

From: The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma

Fig. 6

GO term, KEGG pathway, and GSEA enrichment analyses of HK2-related genes. A-B Heatmap of the top 50 positively and negatively related genes with HK2. C KEGG pathway enrichment analysis using the GSEA database. D-I Gene set enrichment plots of the NF-κB (D), complement and coagulation cascades (E), Toll-like receptor (F), NOD-like receptor (G), Th17 cell differentiation (H), and JAK-STAT (I) signalling pathways. J-M GO and KEGG enrichment analyses of HK2 positively or negatively related genes (Pearson’s rho ≥0.5, P < 0.05). N Expression levels of p-STAT3, STAT3, p-Akt, Akt in HK2-knockdown and control groups in T98 and GBM1 cell lines. Data shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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