Fig. 4

Knockdown of HK2 expression results in the suppression of tumour metastasis and VM Formation in glioma cells. A Representative images and quantification of the inhibition of HK2 expression in si-RNAs targeted HK2 (si-HK2–1 and si-HK2–2)-mediated HK2 knockdown in T98 and GBM1 cell lines. B-C The suppression of HK2 expression can inhibit tumour metastasis by using wound healing (B) and transwell (C) assays in T98 and GBM1 cell lines. D Tube formation assay shows HK2 knockdown could induce the inhibition of VM Formation in glioma cells. Bars, 200 μm. Data shown as mean ± SEM.*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001