Fig. 3From: The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in gliomaEvaluate HK2 gene expression with box plots according to clinical parameters in glioma patients using data from TCGA and CGGA databases. A-B The mRNA expression of HK2 was remarkably correlated with different histological manifestations of glioma in TCGA (A) and CGGA databases (B). C-H The higher mRNA expression of HK2 was associated with shorter OS in different histological manifestations of glioma. I-J Mutation rate of IDH1 in LGG (I) and GBM (J). K-L Mutation rate of IDH2 in LGG (K) and GBM (L). M-N IDH1 mutation in LGG (M) and GBM (N) was associated with OS. O-P HK2 expression was markedly decreased in the IDH mutation group compared to IDH wide type group in TCGA (O) and CGGA databases (P). Q Representative images of HK2 expression in glioma patient specimens at low (10 ×; upper panels) and high (100 ×; lower panels) magnification. R Quantification of the correlation between HK2 expression and malignancy of the glioma specimens. LGG, I and II grades; HGG, III and IV grades. S Overall and disease-free survival rates in low- (n = 40) or high-expression (n = 41) of HK2 in glioma patients. *P < 0.05, **P < 0.01, ***P < 0.001. ****P < 0.0001Back to article page