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Fig. 3 | BMC Cancer

Fig. 3

From: The expression of Hexokinase 2 and its hub genes are correlated with the prognosis in glioma

Fig. 3

Evaluate HK2 gene expression with box plots according to clinical parameters in glioma patients using data from TCGA and CGGA databases. A-B The mRNA expression of HK2 was remarkably correlated with different histological manifestations of glioma in TCGA (A) and CGGA databases (B). C-H The higher mRNA expression of HK2 was associated with shorter OS in different histological manifestations of glioma. I-J Mutation rate of IDH1 in LGG (I) and GBM (J). K-L Mutation rate of IDH2 in LGG (K) and GBM (L). M-N IDH1 mutation in LGG (M) and GBM (N) was associated with OS. O-P HK2 expression was markedly decreased in the IDH mutation group compared to IDH wide type group in TCGA (O) and CGGA databases (P). Q Representative images of HK2 expression in glioma patient specimens at low (10 ×; upper panels) and high (100 ×; lower panels) magnification. R Quantification of the correlation between HK2 expression and malignancy of the glioma specimens. LGG, I and II grades; HGG, III and IV grades. S Overall and disease-free survival rates in low- (n = 40) or high-expression (n = 41) of HK2 in glioma patients. *P < 0.05, **P < 0.01, ***P < 0.001. ****P < 0.0001

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