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Table 2 Colorectal cancer risk among individuals with a family history of CRCa-2 stratified by different first primary cancer diagnosed in their relatives

From: Colorectal cancer risk in association with colorectal cancer as a second malignancy in relatives: a nationwide cohort study

First primary cancer site

Relatives with CRCa-2

N a

RR b

95%CI

UAT

10

2.05

1.10

3.80

Stomach

6

1.50

0.67

3.35

Small intestine

< 5

0.81

0.11

5.75

Liver

< 5

0.59

0.08

4.21

Pancreas

< 5

0.87

0.12

6.19

Lung

< 5

1.21

0.45

3.22

Breast

40

1.67

1.22

2.27

Cervix

10

1.52

0.82

2.83

Endometrium

15

1.46

0.88

2.41

Ovary

8

1.54

0.77

3.08

Female genital

< 5

0.99

0.14

7.06

Prostate

59

1.50

1.16

1.93

Testis

< 5

1.67

0.42

6.69

Male genital

< 5

3.51

0.88

14.02

Kidney

10

2.36

1.27

4.39

Bladder

15

1.25

0.76

2.08

Melanoma

10

1.22

0.65

2.26

Skin

13

1.20

0.70

2.07

Eye

< 5

2.33

0.58

9.32

Nervous system

11

2.71

1.50

4.89

Thyroid

< 5

1.47

0.37

5.87

Endocrine gland

8

1.72

0.86

3.43

Connective tissue

< 5

1.76

0.44

7.05

NHL

6

1.13

0.51

2.53

Hodgkin lymphoma

< 5

3.01

0.75

12.03

Myeloma

< 5

1.84

0.69

4.90

Leukemia

< 5

0.87

0.28

2.70

CUP

< 5

1.43

0.36

5.72

  1. CRCa-2 Colorectal cancer as a second primary malignancy, UAT Upper aerodigestive tract, NHL Non-Hodgkin lymphoma, CUP Cancer of unknown primary
  2. aN, number of CRC cases diagnosed during the follow-up
  3. bRR was estimated from Poisson regression using individuals without cancer family history as the reference. The covariates adjusted in the model included age groups (5 years), periods (5 years), socioeconomic status (blue-collar worker, white-collar worker, farmer, private business, professional, or other/unspecified) and place of residence (big cities, northern Sweden, southern Sweden and unspecific)