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Fig. 3 | BMC Cancer

Fig. 3

From: Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure

Fig. 3

Association of KEGG pathway and clinicopathological characteristics. a Increased activity of Glycan degradation pathway and b Ornithine biosynthesis in metagenomes of patients with positive nodes on imaging. Categorization of patients into the negative (red color) and positive (green color) groups according to absence or presence of cancer cells in lymph nodes respectively revealed that 6 out of 12 patients with negative nodes had very low activity of Glycan degradation pathway. c Increased activity of Glycan degradation pathway and d Ornithine biosynthesis in metagenomes of patients with stage III/IV cervical cancer. e, f Negative association of Phosphotransferase system and of Glycan degradation pathway with recurrence free survival (RFS). Both pathways were enriched in metagenomes of patients with large tumors. The pathway activity was quantified in each metagenome by the mean value of log2-transformed normalized abundances of KOs involved in the pathway; the value is referred to as the pathway activity score, which was categorized as high in the first quartile and low in the rest. g, h Significant positive association of Ribosome biogenesis and of DNA repair pathways with RRS. Both pathways were enriched in metagenomes of patients with small tumors

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