Table 3 Uni- and multivariable logistic regression analysis on the desmoplastic growth pattern

CRLM characteristics

 Disease-free interval^a (cont.)—months

0.98 [0.96–1.01]

0.99 [0.96–1.02]

 Number of CRLM (cont.)

0.93 [0.72–1.21]

-

 Diameter of largest CRLM (cont.)—cm

0.58 [0.41–0.81]

0.55 [0.37–0.82]

 Preoperative CEA (cont.)—100 µg/L

0.42 [0.10–1.68]

-

 Extrahepatic disease—yes vs no

0.28 [0.04–2.22]

-

Classical markers

 Right-sided tumour—yes vs no

0.44 [0.16–1.23]

0.50 [0.16–1.60]

 pT4-stage—yes vs no

0.35 [0.08–1.56]

0.43 [0.08–2.26]

 Positive lymph nodes—yes vs no

0.58 [0.27–1.26]

0.65 [0.25–1.69]

 Tumour deposits—yes vs no

0.40 [0.11–1.41]

0.48 [0.08–2.95]

Invasion markers

 (lympho-)vascular invasion—yes vs no

0.42 [0.17–1.04]

0.68 [0.22–2.12]

 Extramural vascular invasion—yes vs no

0.59 [0.26–1.38]

-

 Perineural invasion—yes vs no

0.43 [0.14–1.30]

1.11 [0.28–4.46]

Tumour interface markers

 Peritumoural budding—Grade II/III vs I

0.44 [0.12–1.53]

0.51 [0.13–2.02]

 CRC growth pattern—Infiltrative vs expanding

0.65 [0.30–1.42]

-

 Non-mature stroma—yes vs no

0.21 [0.06–0.73]

0.29 [0.07–1.25]

Immunological markers

 TIL density (cont.)—10%

1.69 [1.15–2.47]

1.60 [1.01–2.54]