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Table 3 Multivariate adjusted Cox proportional hazard models of the relationship of 5-year overall mortality with time from symptom onset to diagnosis and other factors in patients with cancer of the colon or rectum, colon alone, and rectum alone

From: Relationship between time from symptom’s onset to diagnosis and prognosis in patients with symptomatic colorectal cancer

  Colon and Rectum Model I Colon Model II Rectum Model III
  HR 95% CI HR 95% CI HR 95% CI
Total diagnostic lag time (quartiles)
  1st quartile (< = 1.9 months) 1 1 1
  2nd quartile (1.9–4.2 months) 1.24 (0.80–1.94) 1.10 (0.60–2.04) 1.80 (0.89–3.65)
  3rd quartile (4.2–8.4 months) 0.80 (0.48–1.34) 1.06 (0.54–2.07) 0.63 (0.27–1.49)
  4rd quartile (> 8.4 months) 1.01 (0.62–1.66) 1.09 (0.55–2.16) 1.42 (0.65–3.11)
Age median (IQR) years 1.03 (1.02–1.06) 1.04 (1.01–1.06) 1.05 (1.02–1.09)
Sex
  Men 1 1 1
  Women 0.73 (0.50–1.05) 0.67 (0.42–1.08) 0.67 (0.35–1.29)
Localization
  Colon 1   
  Rectum 1.44 (0.92–2.26) - -
Tumor grade
  Grade I 1 1 1
  Grade II 1.52 (0.96–2.42) 1.30 (0.72–2.33) 2.86 (1.23–6.67)
  Grade III/IV 2.38 (1.20–4.62) 1.44 (0.60–3.43) 7.61 (2.47–23.33)
  Ungraded 1.19 (0.43–3.29) 0.63 (0.08–4.96) 3.34 (0.82–13.70)
Intestinal obstruction
  No 1 1 1
  Yes 1.78 (1.11–2.84) 1.32 (0.77–2.27) 14.61 (4.76–44.84)
Emergency presentation
  No 1 1 1
  Yes 1.44 (0.99–2.08) 1.54 (0.93–2.56) 1.66 (0.91–3.03)
Charlson index
  Median (IQR) 1.15 (1.01–1.33) 1.12 (0.93–1.36) 1.34 (1.05–1.71)
Rectal bleeding
  No 1 1 1
  Yes 0.74 (0.50–1.11) 0.52 (0.28–0.97) 1.26 (0.70–2.24)
Treatment
Surgery
  Curative Resection 1 1 1
  Palliative Resection 4.54 (2.83–7.29) 3.91 (2.06–7.41) 6.58 (2.84–15.23)
Oncological treatment
  No 1 1 1
  Chemotherapy 2.01 (1.26–3.20) 1.87 (1.07–3.28) 2.34 (0.90–6.07)
  Chemotherapy/Radiotherapy 1.68 (0.92–3.07) - 2.99 (1.27–7.04)