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Table 1 Association of sociodemographic factors, clinical factors, and time from symptom onset to diagnosis, with 5-year overall survival in patients with colorectal cancer

From: Relationship between time from symptom’s onset to diagnosis and prognosis in patients with symptomatic colorectal cancer

  Total (n = 779) n/N (%) Deaths at 5 years follow-up (n = 347) HR (95% CI) P value Mortality rate n/N (%)
Time from first symptom presentation to diagnosis (in months) 4.2 (1.9–8.4) 3.7 (1.6–7.5) 0.97 (0.96–0.99) 0.001 NA
First symptom presentation to diagnosis (quartiles)
  1st quartile (< = 1.9 months) 195/779 (25.0) 96/347 (27.7) 1   96/193 (49.7)
  2nd quartile (1.9–4.2 months) 197/779 (25.3) 103/347 (29.7) 1.00 (0.76–1.33) 0.948 103/196 (52.6)
  3rd quartile (4.2–8.4 months) 192/779 (24.2) 71/347 (20.5) 0.67 (0.49–0.91) 0.008 71/187 (38.0)
  4rd quartile (> 8.4 months) 195/779 (24.6) 77/347 (22.2) 0.72 (0.53–0.97) 0.034 77/193 (39.9)
Age median (IQR) years 72 (62 -78) 75 (66–80) 1.04 (1.03–1.05)  < 0.001 NA
Sex
  Men 482/775 (62.2) 227/346 (65.6) 1   227/474 (47.9)
  Women 293/775 (37.8) 119/346 (34.4) 0.87 (0.71–1.07) 0.184 119/291 (40.9)
Level of education
  Primary 504/720 (70.0) 212/296 (71.6) 1   212/497 (42.7)
  High school 170/720 (23.6) 64/296 (21.6) 0.87 (0.66–1.15) 0.326 64/168 (38.1)
  University 46/720 (6.4) 20/296 (6.8) 1.03 (0.65–1.63) 0.901 20/455 (44.4)
Tumor Stage
  0-I 137/701 (19.5) 32/305 (10.5) 1   32/134 (23.9)
  II 226/701 (32.2) 71/305 (23.3) 1.39 (0.93–2.10) 0.101 71/225 (31.6)
  III 202/701 (28.8) 84/305 (27.5) 1.98 (1.33–2.94) 0.001 84/200 (42.0)
  IV 136/701 (19.4) 118/305 (38.7) 8.15 (5.54–12.0)  < 0.001 118/135 (87.4)
Localization
  Colon 470/769 (61.1) 204/340 (60.0) 1   204/464 (44.0)
  Rectum 299/769 (38.9) 136/340 (40.0) 1.04 (0.84–1.30) 0.678 136/295 (46.1)
Tumor grade
  Grade I 166/726 (22.9) 67/326 (20.5) 1   66/163 (40.5)
  Grade II 482/726 (66.4) 214/326 (65.6) 1.22 (0.93–1.61) 0.138 210/475 (44.2)
  Grade III/IV 59/726 (8.1) 34/326 (10.4) 2.04 (1.35–3.09) 0.001 33/59 (55.9)
  Ungraded 19/726 (2.6) 11/326 (3.4) - - 11/19 (57.9)
Intestinal obstruction
  No 659/764 (86.3) 277/342 (81.0) 1   277/651 (42.5)
  Yes 105/764 (13.7) 65/342 (19.0) 1.90 (1.45–2.48)  < 0.001 65/104 (62.5)
Emergency presentation
  No 416/772 (53.9) 157/349 (45.8) 1   157/407 (38.6)
  Yes 356/772 (46.1) 189/349 (54.2) 1.58 (1.28–1.95)  < 0.001 186/355 (52.4)
Perception of seriousness
  Not serious 458/668 (68.6) 197/280(70.4) 1   195/455 (42.9)
  Quite serious 162/668 (24.3) 66/280 (23.6) 1.05 (0.80–1.38) 0.745 66/157 (42.0)
  Very serious 48/668 (7.2) 17/280 (6.1) 0.78 (0.47–1.28) 0.326 17/48 (35.4)
Help seeking behavior
  Wait 184/671 (27.4) 75/277 (27.1) 1   201/480 (41.9)
  Visit doctor 487/671 (72.6) 202/277 (72.9) 1.05 (0.81–1.37) 0.705 75/182 (41.2)
Charlson index
  Median (IQR) 1 (0–2) 1 (0–2) 1.18 (1.11–1.27)  < 0.001 NA
First Symptoms presentation
Abdominal Pain
  No 517/711 (72.7) 220/292 (75.3) 1   220/509 (43.2)
  Yes 194/711 (27.3) 72/292 (24.7) 0.84 (0.65–1.10) 0.207 72/192 (37.5)
Tenesmus
  No 651/711 (91.6) 267/292 (91.4) 1   25/58 (43.1)
  Yes 60/711 (8.4) 25/292 (8.6) 1.04 (0.69–1.57) 0.848 267/643 (41.5)
Rectal bleeding
  No 427/711 (60.1) 191/292 (65.4) 1   191/421 (45.4)
  Yes 284/711 (39.9) 101/292 (34.6) 0.71 (0.56–0.91) 0.008 101/280 (36.1)
Constipation
  No 598/711 (84.1) 232/292 (79.5) 1   60/111 (54.1)
  Yes 113/711 (15.9) 60/292 (20.5) 1.44 (1.08–1.91) 0.015 232/590 (39.3)
Weight loss
  No 654/711 (92.0) 264/292 (90.4) 1   264/645 (40.9)
  Yes 57/711 (8.0) 28/292 (9.6) 1.31 (0.89–1.93) 0.170 28/56 (50.0%)
Anorexia
  No 662/711 (96.1) 267/292 (91.4) 1.53 (1.01–2.31)   267/654 (40.8)
  Yes 49/711 (6.9) 25/292 (8.6) 1 0.042 25/47 (53.2)
Abdominal mass
  No 696/711 (97.9) 285/292 (97.6) 1   285/686 (41.5)
  Yes 15/711 (2.1) 7/292 (2.4) 1.15 (0.54–2.43) 0.701 7/15 (46.7)
Tiredness
  No 614/711 (86.4) 267/292 (84.2) 1   246/607 (40.5)
  Yes 97/711 (13.6) 46/292 (15.8) 1.31 (0.95–1.79) 0.092 46/94 (48.9)
Treatment
Surgery    
  Curative Resection 611/664 (92.0) 231/277 (83.4) 1  < 0.001 231/605 (38.2)
  Palliative Resection 53/664 (7.98) 46/277 (16.6) 4.88 (3.53–6.75)   46/53 (86.8)
Oncological treatment
  No 160/527 (30.4) 51/220 (23.2) 1   
  Chemotherapy 254/527 (48.2) 128/220 (58.2) 1.71 (1.23–2.36)   
  Chemotherapy/Radiotherapy 113/527 (21.4) 41/220 (18.6) 1.10 (0.73–1.66)