Table 1 Association of sociodemographic factors, clinical factors, and time from symptom onset to diagnosis, with 5-year overall survival in patients with colorectal cancer
Total (n = 779) n/N (%) | Deaths at 5 years follow-up (n = 347) | HR (95% CI) | P value | Mortality rate n/N (%) | |
|---|---|---|---|---|---|
Time from first symptom presentation to diagnosis (in months) | 4.2 (1.9–8.4) | 3.7 (1.6–7.5) | 0.97 (0.96–0.99) | 0.001 | NA |
First symptom presentation to diagnosis (quartiles) | |||||
1st quartile (< = 1.9 months) | 195/779 (25.0) | 96/347 (27.7) | 1 | 96/193 (49.7) | |
2nd quartile (1.9–4.2 months) | 197/779 (25.3) | 103/347 (29.7) | 1.00 (0.76–1.33) | 0.948 | 103/196 (52.6) |
3rd quartile (4.2–8.4 months) | 192/779 (24.2) | 71/347 (20.5) | 0.67 (0.49–0.91) | 0.008 | 71/187 (38.0) |
4rd quartile (> 8.4 months) | 195/779 (24.6) | 77/347 (22.2) | 0.72 (0.53–0.97) | 0.034 | 77/193 (39.9) |
Age median (IQR) years | 72 (62 -78) | 75 (66–80) | 1.04 (1.03–1.05) | < 0.001 | NA |
Sex | |||||
Men | 482/775 (62.2) | 227/346 (65.6) | 1 | 227/474 (47.9) | |
Women | 293/775 (37.8) | 119/346 (34.4) | 0.87 (0.71–1.07) | 0.184 | 119/291 (40.9) |
Level of education | |||||
Primary | 504/720 (70.0) | 212/296 (71.6) | 1 | 212/497 (42.7) | |
High school | 170/720 (23.6) | 64/296 (21.6) | 0.87 (0.66–1.15) | 0.326 | 64/168 (38.1) |
University | 46/720 (6.4) | 20/296 (6.8) | 1.03 (0.65–1.63) | 0.901 | 20/455 (44.4) |
Tumor Stage | |||||
0-I | 137/701 (19.5) | 32/305 (10.5) | 1 | 32/134 (23.9) | |
II | 226/701 (32.2) | 71/305 (23.3) | 1.39 (0.93–2.10) | 0.101 | 71/225 (31.6) |
III | 202/701 (28.8) | 84/305 (27.5) | 1.98 (1.33–2.94) | 0.001 | 84/200 (42.0) |
IV | 136/701 (19.4) | 118/305 (38.7) | 8.15 (5.54–12.0) | < 0.001 | 118/135 (87.4) |
Localization | |||||
Colon | 470/769 (61.1) | 204/340 (60.0) | 1 | 204/464 (44.0) | |
Rectum | 299/769 (38.9) | 136/340 (40.0) | 1.04 (0.84–1.30) | 0.678 | 136/295 (46.1) |
Tumor grade | |||||
Grade I | 166/726 (22.9) | 67/326 (20.5) | 1 | 66/163 (40.5) | |
Grade II | 482/726 (66.4) | 214/326 (65.6) | 1.22 (0.93–1.61) | 0.138 | 210/475 (44.2) |
Grade III/IV | 59/726 (8.1) | 34/326 (10.4) | 2.04 (1.35–3.09) | 0.001 | 33/59 (55.9) |
Ungraded | 19/726 (2.6) | 11/326 (3.4) | - | - | 11/19 (57.9) |
Intestinal obstruction | |||||
No | 659/764 (86.3) | 277/342 (81.0) | 1 | 277/651 (42.5) | |
Yes | 105/764 (13.7) | 65/342 (19.0) | 1.90 (1.45–2.48) | < 0.001 | 65/104 (62.5) |
Emergency presentation | |||||
No | 416/772 (53.9) | 157/349 (45.8) | 1 | 157/407 (38.6) | |
Yes | 356/772 (46.1) | 189/349 (54.2) | 1.58 (1.28–1.95) | < 0.001 | 186/355 (52.4) |
Perception of seriousness | |||||
Not serious | 458/668 (68.6) | 197/280(70.4) | 1 | 195/455 (42.9) | |
Quite serious | 162/668 (24.3) | 66/280 (23.6) | 1.05 (0.80–1.38) | 0.745 | 66/157 (42.0) |
Very serious | 48/668 (7.2) | 17/280 (6.1) | 0.78 (0.47–1.28) | 0.326 | 17/48 (35.4) |
Help seeking behavior | |||||
Wait | 184/671 (27.4) | 75/277 (27.1) | 1 | 201/480 (41.9) | |
Visit doctor | 487/671 (72.6) | 202/277 (72.9) | 1.05 (0.81–1.37) | 0.705 | 75/182 (41.2) |
Charlson index | |||||
Median (IQR) | 1 (0–2) | 1 (0–2) | 1.18 (1.11–1.27) | < 0.001 | NA |
First Symptoms presentation | |||||
Abdominal Pain | |||||
No | 517/711 (72.7) | 220/292 (75.3) | 1 | 220/509 (43.2) | |
Yes | 194/711 (27.3) | 72/292 (24.7) | 0.84 (0.65–1.10) | 0.207 | 72/192 (37.5) |
Tenesmus | |||||
No | 651/711 (91.6) | 267/292 (91.4) | 1 | 25/58 (43.1) | |
Yes | 60/711 (8.4) | 25/292 (8.6) | 1.04 (0.69–1.57) | 0.848 | 267/643 (41.5) |
Rectal bleeding | |||||
No | 427/711 (60.1) | 191/292 (65.4) | 1 | 191/421 (45.4) | |
Yes | 284/711 (39.9) | 101/292 (34.6) | 0.71 (0.56–0.91) | 0.008 | 101/280 (36.1) |
Constipation | |||||
No | 598/711 (84.1) | 232/292 (79.5) | 1 | 60/111 (54.1) | |
Yes | 113/711 (15.9) | 60/292 (20.5) | 1.44 (1.08–1.91) | 0.015 | 232/590 (39.3) |
Weight loss | |||||
No | 654/711 (92.0) | 264/292 (90.4) | 1 | 264/645 (40.9) | |
Yes | 57/711 (8.0) | 28/292 (9.6) | 1.31 (0.89–1.93) | 0.170 | 28/56 (50.0%) |
Anorexia | |||||
No | 662/711 (96.1) | 267/292 (91.4) | 1.53 (1.01–2.31) | 267/654 (40.8) | |
Yes | 49/711 (6.9) | 25/292 (8.6) | 1 | 0.042 | 25/47 (53.2) |
Abdominal mass | |||||
No | 696/711 (97.9) | 285/292 (97.6) | 1 | 285/686 (41.5) | |
Yes | 15/711 (2.1) | 7/292 (2.4) | 1.15 (0.54–2.43) | 0.701 | 7/15 (46.7) |
Tiredness | |||||
No | 614/711 (86.4) | 267/292 (84.2) | 1 | 246/607 (40.5) | |
Yes | 97/711 (13.6) | 46/292 (15.8) | 1.31 (0.95–1.79) | 0.092 | 46/94 (48.9) |
Treatment | |||||
Surgery | |||||
Curative Resection | 611/664 (92.0) | 231/277 (83.4) | 1 | < 0.001 | 231/605 (38.2) |
Palliative Resection | 53/664 (7.98) | 46/277 (16.6) | 4.88 (3.53–6.75) | 46/53 (86.8) | |
Oncological treatment | |||||
No | 160/527 (30.4) | 51/220 (23.2) | 1 | ||
Chemotherapy | 254/527 (48.2) | 128/220 (58.2) | 1.71 (1.23–2.36) | ||
Chemotherapy/Radiotherapy | 113/527 (21.4) | 41/220 (18.6) | 1.10 (0.73–1.66) | ||