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Fig. 5 | BMC Cancer

Fig. 5

From: GPX4 suppresses ferroptosis to promote malignant progression of endometrial carcinoma via transcriptional activation by ELK1

Fig. 5

GPX4 promotes EC development, and GPX4 knockdown enhances ferroptosis activity in vivo. A Images of xenograft tumors from BALB/c-nude mice 25 days after the subcutaneous injection of stable GPX4 knockdown Ishikawa cells (shGPX4) or control cells (shNC). B Tumor volume was calculated according to the formula: (length × width2)/2. C Tumor weight of nude mice in shGPX4 and shNC group was assessed on day 25. D Immunohistochemistry and HE stain for GPX4 expression in xenograft tumors. Scale bar: 50 μm. E The concentrations of iron were evaluated in the tumor tissues. F The levels of MDA accumulation were evaluated in the tumor tissues

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BMC Cancer

ISSN: 1471-2407

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