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Fig. 10 | BMC Cancer

Fig. 10

From: Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer

Fig. 10

Silencing KRT7 expression downregulated the expression of E-cadherin and RHOA, and inhibited the cell proliferation, migrative and invasive abilities in both BxPC-3 and CFPAC-1 cell lines. A Western blot images and densitometric quantification of CIC-related protein expression levels in KRT7-knockdown BxPC-3 and CFPAC-1 cells. Relative expression levels were normalized to GAPDH loading control. B and C Effects of silencing KRT7 expression on migration and invasion of BxPC-3 and CFPAC-1 cell lines. Scale bar: 200 μm. D and E Effects of silencing KRT7 expression on cell proliferation of BxPC-3 and CFPAC-1 cell lines. Data represent means ± SD from three independent experiments. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001

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BMC Cancer

ISSN: 1471-2407

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