Table 4 Multivariate analysis of the panel of markers in association with other clinical pathological parameters that may have an impact on survival (* p < 0.05)
Hazard ratio (95.0% CI) | p-value | |
|---|---|---|
Differentiation | ||
Mild | 1(-) | 0 |
Moderate | 0.596 (0.112-3.180) | 0.545 |
Poor | 0.801 (0.46-1.394) | 0.432 |
Histological T staging | ||
T I | 1(-) | 0 |
T II | 0.938 (0.144-6.129) | 0.947 |
T III | 0.696 (0.11-4.409) | 0.701 |
T IV | 1.116 (0.219-5.688) | 0.895 |
Lymphovasular invasion | ||
Negative v’s Positive | 0.528 (0.251-1.111) | 0.093 |
Mandard classification | ||
No response | 1.586 (0.297-8.457) | 0.589 |
Response | 1.726 (0.403-7.387) | 0.462 |
PET response | ||
PET Responder | 0.845 (0.443-1.611) | 0.610 |
PET Non-responder | 0.622 (0.333-1.160) | 0.135 |
Markers panel | ||
All are negative | 1(-) | 0 |
LC3B globular and LC3B cytoplasmic are negative and CC3 is positive | 0.489 (0.165-1.446) | 0.196 |
CC3 is negative and LC3B globular and LC3B cytoplasmic are positive | 0.046 (0.005-0.443) | 0.008* |
All are positive | 1.202 (0.565-1.658) | 0.299 |
Circumferential margin | ||
Negative vs Positive | 1.202 (0.626-2.309) | 0.581 |
Lymph Node stage(N stage) | ||
N stage 0 | 1(-) | 0 |
N stage I | 0.233 (0.097-0.557) | 0.001* |
N stage II | 0.395 (0.192-0.812) | 0.012 |
N stage III | 0.830 (0.434-1.589) | 0.574 |