Table 1 Patient demographics and clinical characteristics
GEM arm (n = 20) | GEM + SBRT arm (n = 18) | P | |
|---|---|---|---|
Age, y, median (IQR) | 58.5 (50.3–67.3) | 63.0 (58.8–66.0) | 0.176 |
Sex, male, n (%) | 12 (60.0%) | 13 (72.2%) | |
BMI, Kg/m2, median (IQR) | 22.2 (20.4–25.0) | 23.3 (22.0–24.8) | 0.361 |
ECOG, n (%) | 0.825 | ||
0 | 14 (70.0%) | 12 (66.7%) | |
1 | 6 (30.0%) | 6 (33.3%) | |
Preoperative CA19-9, U/L, median (IQR) | 267.9 (38.8–737.3) | 575.3 (105.8–1921.0) | 0.305 |
CA19-9 on randomization, U/L, median (IQR) | 24.4 (5.3–105.5) | 126 (7.2–375.5) | 0.160 |
Post-operative complications (Clavien-Dido ≥ grade III), n (%) | 5 (25.0%) | 7 (38.9%) | 0.358 |
Surgery to adjuvant chemotherapy, d, median (IQR) | 41.5 (35.5 – 45.0) | 62.5 (51.0 – 69.3) | < 0.001 |
Number of dissected lymph nodes, median (IQR) | 20.0 (12.3 – 23.8) | 20.5 (16.5 – 29.3) | 0.276 |
Number of positive lymph nodes, median (IQR) | 1.00 (0–3.0) | 2.00 (0.8 – 4.0) | 0.534 |
Number of node-positive patients, n (%) | 12 (60.0%) | 13 (72.2%) | 0.428 |
Maximum tumor size, mm, median (IQR) | 3 (2.3–3.9) | 3 (2.4–3.7) | 0.828 |
Procedure, n (%) | 0.084 | ||
Pancreaticoduodenectomy | 13 (65.0%) | 16 (88.9%) | |
Distal pancreatectomy | 7 (35.0%) | 2 (11.1%) | |
Combined vascular resection, n (%) | 5 (25.0%) | 6 (33.3%) | 0.572 |
Combined organ resection, n (%) | 1 (5.0%) | 0 | 0.336 |