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Table 6 Statistical analysis of patient characteristics of OS data

From: The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010

 

Univariate analysis

Multivariate analysis

p-value

HR [95%CI]

p-value

HR [95%CI]

Age

 < 0.001

1.038 [ 1.027–1.049]

 < 0.001

1.032 [1.017—1.048]

Gender (female vs. male)

 < 0.001

0.491 [0.409–0.591]

0.447

0.884 [0.643—1.215]

Smoking History (+ vs. –)

 < 0.001

2.108 [1.741–2.554]

0.172

1.265 [0.903—1.771]

Operation time

 < 0.001

1.003 [1.002–1.004]

0.016

1.002 [1.001–1.004]

Invasion

 

 Lymphatic vessel invasion (+ vs. –)

 < 0.001

3.056 [2.533–3.685]

0.378

1.140 [0.852—1.525]

 

 Vascular invasion (+ vs. –)

 < 0.001

3.125 [2.597–3.759]

0.015

1.417 [1.071—1.874]

 

 Pleural invasion (+ vs. –)

 < 0.001

2.519 [2.113–3.004]

0.518

1.096 [0.830—1.447]

Adenocarcinoma predominance

 AIS + MIA

 

control

 

control

 Lepidic

0.198

1.360[0.852–2.172]

0.998

0.999 [0.455—2.197]

 Acinar + Papillary + Variants

 < .001

2.600 [1.745–3.876]

0.380

1.366 [0.681—2.739]

 Solid + Micropapillary

 < .001

5.178 [3.355–7.991]

0.041

2.182 [1.031—4.617]

 EGFR status (+ vs. –)

 < 0.001

0.551 [0.439–0.692]

0.050

0.762 [0.581—1.000]

 Adjuvant chemotherapy (+ vs. –)

 < 0.001

0.645 [0.769–0.541]

0.034

0.740 [0.561—0.977]

Clinical stage

 

 Stage IA

 

control

 

control

 

 Stage IB

 < 0.001

1.778[1.445—2.188]

0.796

1.041 [0.767—1.414]

 

 Stage IIA

 < 0.001

3.032 [2.295—4.005]

0.358

1.204 [0.810—1.790]

 

 Stage IIB

 < 0.001

2.853 [1.911—4.259]

0.701

0.882 [0.466—1.671]

 

 Stage IIIA

 < 0.001

4.581 [3.347—6.270]

0.938

0.981 [0.602—1.597]

Pathological stage

 

 Stage IA

 

control

 

control

 

 Stage IB

 < 0.001

2.038 [1.578—2.631]

0.026

1.640 [1.062—2.534]

 

 Stage IIA

 < 0.001

4.513 [3.419—5.957]

 < 0.001

2.588 [1.622—4.131]

 

 Stage IIB

 < 0.001

4.961 [3.440—7.154]

0.027

2.063 [1.087—3.915]

 

 Stage IIIA

 < 0.001

6.695 [5.244—8.548]

 < 0.001

4.112 [2.559—6.606]

  1. HR Hazard ratio