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Table 6 Statistical analysis of patient characteristics of OS data

From: The prognostic impact of lung adenocarcinoma predominance classification relating to pathological factors in lobectomy, the Japanese Joint Committee of Lung Cancer Registry Database in 2010

  Univariate analysis Multivariate analysis
p-value HR [95%CI] p-value HR [95%CI]
Age  < 0.001 1.038 [ 1.027–1.049]  < 0.001 1.032 [1.017—1.048]
Gender (female vs. male)  < 0.001 0.491 [0.409–0.591] 0.447 0.884 [0.643—1.215]
Smoking History (+ vs. –)  < 0.001 2.108 [1.741–2.554] 0.172 1.265 [0.903—1.771]
Operation time  < 0.001 1.003 [1.002–1.004] 0.016 1.002 [1.001–1.004]
Invasion
   Lymphatic vessel invasion (+ vs. –)  < 0.001 3.056 [2.533–3.685] 0.378 1.140 [0.852—1.525]
   Vascular invasion (+ vs. –)  < 0.001 3.125 [2.597–3.759] 0.015 1.417 [1.071—1.874]
   Pleural invasion (+ vs. –)  < 0.001 2.519 [2.113–3.004] 0.518 1.096 [0.830—1.447]
Adenocarcinoma predominance
 AIS + MIA   control   control
 Lepidic 0.198 1.360[0.852–2.172] 0.998 0.999 [0.455—2.197]
 Acinar + Papillary + Variants  < .001 2.600 [1.745–3.876] 0.380 1.366 [0.681—2.739]
 Solid + Micropapillary  < .001 5.178 [3.355–7.991] 0.041 2.182 [1.031—4.617]
 EGFR status (+ vs. –)  < 0.001 0.551 [0.439–0.692] 0.050 0.762 [0.581—1.000]
 Adjuvant chemotherapy (+ vs. –)  < 0.001 0.645 [0.769–0.541] 0.034 0.740 [0.561—0.977]
Clinical stage
   Stage IA   control   control
   Stage IB  < 0.001 1.778[1.445—2.188] 0.796 1.041 [0.767—1.414]
   Stage IIA  < 0.001 3.032 [2.295—4.005] 0.358 1.204 [0.810—1.790]
   Stage IIB  < 0.001 2.853 [1.911—4.259] 0.701 0.882 [0.466—1.671]
   Stage IIIA  < 0.001 4.581 [3.347—6.270] 0.938 0.981 [0.602—1.597]
Pathological stage
   Stage IA   control   control
   Stage IB  < 0.001 2.038 [1.578—2.631] 0.026 1.640 [1.062—2.534]
   Stage IIA  < 0.001 4.513 [3.419—5.957]  < 0.001 2.588 [1.622—4.131]
   Stage IIB  < 0.001 4.961 [3.440—7.154] 0.027 2.063 [1.087—3.915]
   Stage IIIA  < 0.001 6.695 [5.244—8.548]  < 0.001 4.112 [2.559—6.606]
  1. HR Hazard ratio