Serum 25-hydroxyvitamin D and cancer-related fatigue: associations and effects on depression, anxiety, functional capacity and health-related quality of Life in breast cancer survivors during adjuvant endocrine therapy

Custódio, Isis Danyelle Dias; Nunes, Fernanda Silva Mazzutti; Lima, Mariana Tavares Miranda; de Carvalho, Kamila Pires; Alves, Débora Santana; Chiaretto, Juliana Freitas; Canto, Paula Philbert Lajolo; Paiva, Carlos Eduardo; de Paiva Maia, Yara Cristina

doi:10.1186/s12885-022-09962-x

Table 4 Associations and effects of anthropometric and body composition parameters on cancer-related fatigue

From: Serum 25-hydroxyvitamin D and cancer-related fatigue: associations and effects on depression, anxiety, functional capacity and health-related quality of Life in breast cancer survivors during adjuvant endocrine therapy

Independent variable¹	Baseline (n = 89)								Longitudinal phase (n = 38) FACIT-Fatigue (Mean ± SD)
	FACIT-Fatigue		p	β	95% CI		Wald Chi-Square	*p	Independent Variable		Time points			Model Effects Test
	Score < 34 (n = 32)	Score ≥ 34 (n = 57)	p	β	Lower	Upper	Wald Chi-Square	*p	Independent Variable		T0	T1	T2	Effects	Df	**p
BMI (Kg/m²)	30.5 (26.3–34.9)	26.8 (25.1–30.1)	0.002^‡	-0.637	-0.986	-0.287	12.760	< 0.001	BMI (Kg/m²)		36.64 ± 2.75	39.01 ± 2.11	40.45 ± 2.86	Time points	2	0.547
									Without overweight	37.07 ± 2.68	36.58 ± 3.45	36.32 ± 2.86	38.31 ± 3.32	BMI	1	0.223
									Overweight	40.33 ± 2.20	36.69 ± 2.76	41.71 ± 2.27	42.59 ± 3.18	Interaction²	2	0.083
WC (cm)	98.0 (88.6–102.9)	90.5 (82.0–95.0)	0.004^‡	-0.265	-0.427	-0.103	10.310	0.001	WC (cm)		40.94 ± 2.92	45.65 ± 2.87	42.30 ± 3.06	Time points	2	0.137
									< 80	46.98 ± 3.00^a	44.80 ± 3.82	51.75 ± 4.61	44.40 ± 3.81	WC	1	0.001
									≥ 80	38.94 ± 2.04^b	37.08 ± 2.67	39.55 ± 2.06	40.21 ± 2.91	Interaction²	2	0.243
WHR	0.91 (0.07)	0.9 (0.1)	0.214^†	-19.649	-49.249	9.951	1.693	0.193	WHR		37.78 ± 2.70	40.27 ± 2.14	41.03 ± 2.91	Time points	2	0.513
									≤ 0.85	40.52 ± 2.32	38.44 ± 3.11	41.29 ± 2.68	41.82 ± 3.22	WHR	1	0.402
									> 0.85	38.87 ± 2.24	37.13 ± 2.82	39.25 ± 2.27	40.23 ± 3.18	Interaction²	2	0.964
WHtR	0.6 (0.6–0.7)	0.6 (0.5–0.6)	0.002^‡	-41.972	-67.155	-16.788	10.670	0.001	WHtR		38.83 ± 3.50	44.29 ± 2.92	41.87 ± 3.63	Time points	2	0.196
									< 0.5	43.77 ± 3.95	39.91 ± 5.46	48.78 ± 4.77	42.61 ± 5.60	WHtR	1	0.249
									≥ 0.5	39.56 ± 2.03	37.75 ± 2.66	39.79 ± 2.06	41.13 ± 2.88	Interaction²	2	0.329
Body Fat (Kg)	31.5 (25.2–40.2)	27.7 (23.4–32.9)	0.092^‡	-0.285	-0.526	-0.045	5.393	0.020	Body Fat (Kg)		38.79 ± 2.94	40.76 ± 2.39	39.59 ± 3.32	Time points	2	0.348
									≤ 28.21	40.04 ± 2.45	40.42 ± 3.27	40.04 ± 2.71	39.67 ± 3.34	Body Fat (Kg)	1	0.770
									> 28.21	39.39 ± 2.70	37.16 ± 3.25	41.48 ± 2.74	39.51 ± 3.94	Interaction²	2	0.259
Body Fat (%)	41.2 (36.9–47.8)	40.0 (36.8–43.7)	0.271^‡	-0.322	-0.718	0.074	2.543	0.111	Body Fat (%)		38.61 ± 2.94	41.04 ± 2.38	40.53 ± 3.28	Time points	2	0.384
									≤ 40.35	39.56 ± 2.46	39.18 ± 3.24	40.26 ± 2.72	39.23 ± 3.33	Body Fat (%)	1	0.627
									> 40.35	40.56 ± 2.59	38.03 ± 3.23	41.82 ± 2.68	41.83 ± 3.83	Interaction²	2	0.539
Conicity Index	1.3 (0.1)	1.3 (0.1)	0.152^†	-20.073	-45.098	4.953	2.471	0.116	Conicity Index		36.79 ± 2.73	39.54 ± 2.13	40.13 ± 2.95	Time points	2	0.409
									≤ 1.3	40.62 ± 2.18^a	39.21 ± 2.84	40.49 ± 2.41	42.18 ± 3.08	CI	1	0.021
									> 1.3	37.01 ± 2.29^b	34.36 ± 3.03	38.59 ± 2.34	38.08 ± 3.17	Interaction²	2	0.475

^†Test-t Independent; ^‡Mann–Whitney; Continuous variables are shown as mean (standard deviation) or median (p25-p75); *Generalized linear models (GLzM); **General Mixed Model (GMM); Data adjusted for age, education level, income and usage time of aromatase inhibitors. FACIT-Fatigue, Functional Assessment of Chronic Illness Therapy—Fatigue Scale, with cut-off < 34 indicating cancer-related fatigue; Time point: T0, Baseline; T1, Intermediate period, corresponding to 12 months after T0; and T2, Final follow-up period, corresponding to 24 months after T0; SD, Standard deviation; Df, degrees of freedom; BMI, body mass index; WC, waist circumference; WHR, waist-to-hip ratio; WHtR, waist-to-height ratio. Significant Model Effects Test are in bold. Sidak test: Different superscript letters represent statistical significance when comparing pairs, p value < 0.05. ¹Continuous variable. ²Interaction between anthropometric/ body composition parameters and time points of study. The variables Body Fat and Conicity Index were categorized by the medians

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