Table 2 The clinicopathologic significance of IGF-1R and Livin expression in patients with CRC (N = 60)
Characteristics | Number | IGF-1R expression | P-value | Livin expression | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
– | + | ++ | +++ | – | + | ++ | +++ | ||||
Age,years | 0.824 | 0.760 | |||||||||
< 50 | 8 | 1 | 2 | 4 | 1 | 4 | 2 | 2 | 0 | ||
50–70 | 37 | 6 | 10 | 8 | 13 | 11 | 15 | 8 | 3 | ||
≥ 71 | 15 | 2 | 5 | 6 | 2 | 8 | 4 | 3 | 0 | ||
Gender | 0.847 | 0.889 | |||||||||
Male | 33 | 6 | 7 | 11 | 9 | 13 | 11 | 7 | 2 | ||
Female | 27 | 3 | 10 | 7 | 7 | 10 | 10 | 6 | 1 | ||
Tumor diameter, cm | 0.852 | 0.831 | |||||||||
< 5 | 40 | 6 | 11 | 12 | 11 | 17 | 12 | 8 | 3 | ||
≥ 5 | 20 | 3 | 6 | 6 | 5 | 6 | 9 | 5 | 0 | ||
Tumor location | 0.059 | 0.918 | |||||||||
Right colon | 16 | 2 | 5 | 6 | 3 | 4 | 9 | 2 | 1 | ||
Left colon | 18 | 1 | 6 | 7 | 4 | 5 | 7 | 6 | 0 | ||
Rectum | 26 | 6 | 6 | 5 | 9 | 14 | 5 | 5 | 2 | ||
Pathological type | 0.363 | 0.847 | |||||||||
Adenocarcinoma | 56 | 8 | 15 | 18 | 15 | 22 | 19 | 12 | 3 | ||
Mucinous adenocarcinoma | 4 | 1 | 2 | 0 | 1 | 1 | 2 | 1 | 0 | ||
Histological type | 0.598 | 0.328 | |||||||||
Moderately-Well differentiated | 54 | 8 | 15 | 16 | 15 | 20 | 18 | 13 | 3 | ||
Poorly differentiated | 6 | 1 | 2 | 2 | 1 | 3 | 3 | 0 | 0 | ||
Depth of invasion | 0.004 | 0.291 | |||||||||
Tis-T1 | 8 | 2 | 5 | 1 | 0 | 4 | 3 | 1 | 0 | ||
T2-T4 | 52 | 7 | 12 | 17 | 16 | 19 | 18 | 12 | 3 | ||
Dukes’ stage | 0.000 | 0.044 | |||||||||
A | 15 | 6 | 6 | 2 | 1 | 9 | 5 | 1 | 0 | ||
B | 15 | 2 | 7 | 5 | 1 | 5 | 7 | 3 | 0 | ||
C | 15 | 1 | 3 | 6 | 5 | 6 | 4 | 5 | 0 | ||
D | 15 | 0 | 1 | 5 | 9 | 3 | 5 | 4 | 3 | ||
Lymph node metastasis | 0.000 | 0.022 | |||||||||
Absent | 33 | 8 | 13 | 8 | 4 | 16 | 12 | 4 | 1 | ||
Present | 27 | 1 | 4 | 10 | 12 | 7 | 9 | 9 | 2 | ||
Distant metastasis | 0.000 | 0.032 | |||||||||
Absent | 45 | 9 | 16 | 13 | 7 | 20 | 16 | 9 | 0 | ||
Present | 15 | 0 | 1 | 5 | 9 | 3 | 5 | 4 | 3 | ||