Fig. 3

Elevated IGF-1R expression is associated with the tumorigenesis and progression of CRC. The correlation between IGF-1R gene expression and CRC clinicopathological features, including age (A), gender (B), histological subtype (C), individual cancer stages (D), nodal metastasis status (E), promoter methylation (F), and TP53-mutant (G) in TCGA. H The expression of IGF-1R protein in Dukes’ A, B, C, and D of CRC (400×, scale = 10 μm). IGF-1R, insulin-like growth factor 1 receptor; CRC, colorectal cancer; TCGA, The Cancer Genome Atlas. *P < 0.05, **P < 0.01, and ***P < 0.001