Fig. 5

TMB and MSI of clusters for validation. A Radar chart of nine genes on TMB (* means p < 0.05, **p < 0.01 and ***p < 0.001, ACC: adrenocortical cancer, BLCA: bladder cancer, BRCA: breast cancer, CESC: cervical cancer, COAD: colon cancer, CHOL: bile duct cancer, DLBC: large B-cell lymphoma, ESCA: esophageal cancer, GBM: glioblastoma, HNSC: head and neck cancer, KICH: kidney chromophobe, KIRC: kidney clear cell carcinoma, KIRP: kidney papillary cell carcinoma, LAML: acute myeloid leukemia, LGG: lower grade glioma, LIHC: liver cancer, LUAD: lung adenocarcinoma, LUSC: lung squamous cell carcinoma, MESO: mesothelioma, OV: ovarian cancer, PAAD: pancreatic cancer, PCPG: pheochromocytoma & paraganglioma, PRAD: prostate cancer, READ: rectal cancer, SARC: sarcoma, SKCM: melanoma, STAD: stomach cancer, TGCT: testicular cancer, THCA: thyroid cancer, THYM: thymoma, UCEC: endometrioid cancer, UCS: uterine carcinosarcoma, UVM: andocular melanomas). B Waterfall plot of TMB in clusters. C The TMB level between two clusters of colon cancer cases. D The percentage weight of MSI status between two clusters in the TCGA cohort