Variable | HoR + /HER2- | HoR + /HER2 + | HoR-/HER2 + | HoR-/HER2- | ||||
---|---|---|---|---|---|---|---|---|
Multivariate Analysis | Multivariate Analysis | Multivariate Analysis | Multivariate Analysis | |||||
HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | |
GRADE | ||||||||
I | reference | reference | reference | reference | ||||
II | 1.27(0.92–1.77) | 0.14 | 1.02(0.54–1.93) | 0.95 | 0.19(0.04–0.88) | 0.03 | 1.71(0.69–4.24) | 0.25 |
III | 1.74(1.26–2.40) | < 0.01 | 1.12(0.58–2.13) | 0.74 | 0.19(0.04–0.83) | 0.03 | 2.19(0.90–5.31) | 0.08 |
SURGERY | ||||||||
Breast-conserving | reference | reference | reference | reference | ||||
Total mastectomy | 0.54(0.40–0.74) | < 0.0001 | 0.60(0.40–0.89) | 0.01 | 0.41(0.21–0.78) | 0.01 | 0.67(0.49–0.91) | 0.01 |
Modified radical mastectomy | 0.75(0.52–1.09) | 0.13 | 0.52(0.29–0.93) | 0.03 | 0.53(0.23–1.21) | 0.13 | 0.55(0.36–0.85) | 0.01 |
RADIATION | ||||||||
No | reference | reference | reference | reference | ||||
Yes | 0.36(0.26–0.48) | < 0.0001 | 0.37(0.25–0.56) | < 0.0001 | 0.36(0.16–0.77) | 0.01 | 0.48(0.35–0.66) | < 0.0001 |
CHEMOTHERAPY | ||||||||
No | reference | reference | reference | reference | ||||
Yes | 0.61(0.51–0.74) | < 0.0001 | 0.42(0.30–0.58) | < 0.0001 | 0.33(0.19–0.59) | < 0.0001 | 0.35(0.27–0.44) | < 0.0001 |
AGE (year) | ||||||||
< 60 | reference | reference | reference | reference | ||||
≥ 60 | 3.62(2.98–4.41) | < 0.0001 | 3.27(2.13–5.02) | < 0.0001 | 2.59(1.34–5.04) | < 0.01 | 2.01(1.50–2.69) | < 0.0001 |