Variables | T1a | T1b | T1c | |||
---|---|---|---|---|---|---|
Multivariate Analysis | Multivariate Analysis | Multivariate Analysis | ||||
HR (95%CI) | P-value | HR (95%CI) | P-value | HR (95%CI) | P-value | |
GRADE | ||||||
I | reference | reference | reference | |||
II | 2.17(0.98–4.83) | 0.06 | 1.01(0.89–1.14) | 0.92 | 1.25(0.95–1.63) | 0.11 |
III | 2.24(0.95–5.27) | 0.07 | 1.19(0.99–1.43) | 0.06 | 1.59(1.22–2.08) | < 0.01 |
SURGERY | ||||||
Breast-conserving | reference | reference | reference | |||
Total mastectomy | 0.67(0.31–1.43) | 0.30 | 0.74(0.63–0.88) | < 0.01 | 0.58(0.48–0.69) | < 0.0001 |
Modified radical mastectomy | 0.26(0.08–0.85) | 0.03 | 0.96(0.77–1.19) | 0.70 | 0.63(0.50–0.80) | < 0.01 |
RADIATION | ||||||
No | reference | reference | ||||
Yes | 0.32(0.15–0.70) | < 0.01 | 0.72(0.59–0.88) | < 0.0001 | 0.39(0.33–0.47) | < 0.0001 |
CHEMOTHERAPY | ||||||
No | reference | reference | reference | |||
Yes | 1.09(0.67–1.76) | 0.73 | 0.44(0.38–0.51) | < 0.0001 | 0.47(0.41–0.54) | < 0.0001 |
SUBTYPE | ||||||
HoR + /HER2- | reference | reference | reference | |||
HoR + /HER2 + | 0.35(0.16–0.75) | 0.01 | 1.32(1.05–1.68) | 0.02 | 1.31(1.09–1.57) | < 0.01 |
HoR-/HER2 + | 0.70(0.35–1.38) | 0.30 | 1.64(1.14–2.37) | 0.01 | 1.41(1.06–1.86) | 0.02 |
HoR-/HER2- | 0.55(0.27–1.13) | 0.10 | 1.65(1.33–2.05) | < 0.0001 | 1.83(1.57–2.14) | < 0.0001 |
AGE (year) | ||||||
< 60 | reference | reference | reference | |||
≥ 60 | 3.22(1.95–5.31) | < 0.0001 | 3.72(3.17–4.36) | < 0.0001 | 3.08(2.65–3.58) | < 0.0001 |