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Table 2 Relationship of KK-LC-1 with immune cell type markers by TIMER database

From: Cancer-testis antigen KK-LC-1 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma

Description

Marker genes

None Cor

P

Purity Cor

P

B Cell

CD19

0.097

*

0.088

0.052

 

CD79A

0.095

*

0.079

0.081

T Cell (general)

CD3D

0.019

0.672

−0.016

0.722

 

CD3E

−0.013

0.761

−0.054

0.229

 

CD2

−0.037

0.403

− 0.082

0.068

CD8 + T Cell

CD8A

0.04

0.36

0.015

0.738

 

CD8B

0.03

0.501

0.009

0.837

 

CD45(PTPRC)

−0.099

*

−0.146

**

Monocyte

CD86

−0.083

0.061

−0.129

**

 

CD115(CSF1R)

−0.171

***

−0.215

***

M1 Macrophage

INOS (NOS2)

0.123

**

0.114

*

 

IRF5

−0.016

0.721

−20.29

0.516

 

COX2(PTGS2)

0.065

0.14

0.058

0.196

M2 Macrophage

CD163

−0.08

0.069

−0.114

*

 

VSIG4

−0.126

**

−0.158

***

 

MS4A4A

−0.107

*

−0.143

**

TAM

CD68

−0.08

0.071

−0.111

*

 

IL10

−0.052

0.243

−0.068

0.13

 

CCL2

−0.073

0.097

−0.092

*

Neutrophil

CD66b (CEACAM8)

−0.169

***

−0.186

***

 

CD15(FUT4)

0.094

*

0.101

*

 

CCR7

−0.03

0.493

−0.061

0.173

Natural killer cell

KIR2DL1

0.008

0.849

−0.008

0.854

 

KIR2DL3

0.034

0.447

0.026

0.0572

 

KIR2DL4

0.142

**

0.135

**

 

KIR3DL1

0.087

*

0.089

*

 

KIR3DL2

0.047

0.288

0.045

0.318

 

KIR3DL3

0.116

0.087

0.116

**

 

KIR2DS4

0.024

0.585

0.022

0.623

Dendritic cell

BDCA-1 (CD1C)

−0.214

***

−0.238

***

 

BDCA-3 (THBD)

−0.16

***

−0.175

***

 

BDCA-4 (NRP1)

−0.032

0.472

−0.036

0.426

 

CD11c (ITGAX)

−0.053

0.227

−0.088

0.051

Th1

T-bet (TBX21)

−0.024

0.582

−0.047

0.293

 

STAT4

−0.014

0.752

−0.046

0.309

 

TNF-α (TNF)

−0.061

0.169

−0.084

0.062

 

STAT1

0.065

0.143

0.046

0.306

Th2

GATA3

−0.031

0.483

−0.073

0.105

 

STAT5A

−0.122

**

−0.152

***

 

STAT6

−0.027

0.534

−0.033

0.465

Tfh

BCL6

0.021

0.641

0.017

0.714

 

IL21

0.047

0.292

0.021

0.641

Th17

STAT3

0.029

0.516

0.03

0.454

 

IL17A

0.055

0.214

0.05

0.266

Treg

FOXP3

0.015

0.738

−0.025

0.582

 

CD25(IL2RA)

−0.026

0.553

−0.059

0.195

 

CCR8

0.007

0.882

−0.082

0.542

 

TGFβ (TGFB1)

−0.064

0.167

−0.075

0.095

 

STAT5B

−0.021

0.639

−0.01

0.828

T cell exhaustion

PD-1 (PDCD1)

0.021

0.633

−0.001

0.986

 

CTLA4

0.009

0.839

−0.023

0.603

 

LAG3

0.013

0.763

−0.003

0.940

 

TIM-3 (HAVCR2)

−0.088

*

−0.139

**

 

GZMB

0.13

**

0.114

*

  1. Cor, R value of Spearman’s correlation; None, correlation without adjustment;Purity,correlation adjusted by purity; TAM tumor-associated macrophage; Th T helper cell; Tfh Follicular helper T cell; Treg regulatory T cell. (∗p < 0.01, ∗∗p < 0.001, ∗∗∗p < 0.0001)
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BMC Cancer

ISSN: 1471-2407

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