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Fig. 5 | BMC Cancer

Fig. 5

From: Lycorine inhibits angiogenesis by docking to PDGFRα

Fig. 5

Lyc inhibited PDGFRα activition and virtual verification of Lyc targets by molecular docking. A Western blot analysis of total-cell extracts of HUVECs treated with Lyc for 24 h to evaluate the effect of Lyc on PDGFRα. Proteins in PDGFRα pathways, including PDGFRα, PI3K and AKT, were measured by western blotting. β-actin was used as internal control. B P-PDGFRα expression was assessed by immunofluorescence staining. Nuclei were visualized with hoechst (blue). Scale bars represented 100 um. The bar graphes in the lower right corner represented relative expression level of p-PDGFRα in western blotting and immunofluorescence staining. Besides, all of the uncropped western blot gels in Supplementary Information 2

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