Fig. 8

Expression of S100A14 in tumor cells and its relationship with PD-L1/2 expression. A A pan-cancer analysis of S100A14 on 33 types of tumors. Red represented a significant increase in tumor, green represented a significant decrease in tumor, and black meant no significant change. B Comparison of S100A14 expression between pancreatic normal ductal and PC cell lines detected by qRT-PCR. The difference between each PC cell line and HPNE was analyzed. C Comparison of S100A14 expression between pancreatic normal ductal and PC cell lines detected by western blot. D Relationship between S100A14 expression and PD-L1/2 expression at RNA level in PC cell lines. E Relationship between S100A14 expression and PD-L1 expression at protein level in PC cell lines. F Representative images of PD-L1 expression in S100A14 high and low expression group in PUMCH cohort. G Comparison of PD-L1 expression in S100A14 high and low expression group in PUMCH cohort. H Prediction of major downstream regulators caused by elevated S100A14 using iRegulon tools. I Relationship between S100A14 expression and FOXL1 expression