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Fig. 5 | BMC Cancer

Fig. 5

From: Exosome-derived lnc-HOXB8-1:2 induces tumor-associated macrophage infiltration to promote neuroendocrine differentiated colorectal cancer progression by sponging hsa-miR-6825-5p

Fig. 5

Association between lnc-HOXB8-1:2 and CXCR3 in TAMs. A, The rising expression of CXCR3 and lnc-HOXB8-1:2 in TAMs (stained by CD68) that infiltrated neuroendocrine differentiated CRC tissue specimens showed by successive tissue sections. Scale bar =100μm and 20 μm. B-D, The expression of CD68, lnc-HOXB8-1:2 and CXCR3 in the NED group were significantly upregulated. E, Correlation analysis found that a significant positive correlation existed between CD68 and lnc-HOXB8-1:2, CXCR3 and CD68, CXCR3 and lnc-HOXB8-1:2. F, qRT–PCR assay revealed an increase of lnc-HOXB8-1:2 in TAMs cocultured with CgA Exo. *, P < 0.05; **, P < 0.01; ***, P < 0.001; TAMs, tumor-associated macrophages; NC, negative control; NED, neuroendocrine differentiation; non-NED, non-neuroendocrine differentiation; CgA, chromogranin A; Exo, exosomes

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BMC Cancer

ISSN: 1471-2407

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