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Fig. 1 | BMC Cancer

Fig. 1

From: Exosome-derived lnc-HOXB8-1:2 induces tumor-associated macrophage infiltration to promote neuroendocrine differentiated colorectal cancer progression by sponging hsa-miR-6825-5p

Fig. 1

Neuroendocrine differentiation predicted poor prognosis of CRC patients and corelated with macrophage infiltration. A, Kaplan–Meier progression-free survival curve of patients in the NED group and the non-NED group. B, Kaplan–Meier overall survival curve of patients in the NED group and the non-NED group. C, Data from Timer 2.0 database showed the association between CgA gene expression level and macrophage infiltration. D, The correlation between CXCR3 gene expression level and macrophage infiltration. E, Tumor-associated macrophages (stained by CD68) clustered around neuroendocrine differentiated cells (stained by CgA). Scale bar = 100μm and 20 μm. F, The percentage of tumor-associated macrophages containing CD68 staining in the NED group was significantly increased compared to the non-NED group. *, P < 0.05; **, P < 0.01; ***, P < 0.001; NED, neuroendocrine differentiation; non-NED, non-neuroendocrine differentiation; COAD, colon adenocarcinoma; READ, rectal adenocarcinoma; CgA, chromogranin A

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BMC Cancer

ISSN: 1471-2407

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