Table 3 Treatment-related toxicities
Total (n = 265) | Low EASIX (n = 172) | High EASIX (n = 93) | P | |
|---|---|---|---|---|
Hematologic toxicity, grade ≥ 3 | ||||
Anemia | 53 (20) | 21 (12.2) | 32 (34.4) | < 0.001 |
Thrombocytopenia | 75 (28.3) | 25 (14.5) | 50 (53.8) | < 0.001 |
Neutropenia | 206 (77.7) | 124 (72.1) | 82 (88.2) | 0.003 |
Febrile neutropenia | 76 (28.7) | 32 (18.6) | 44 (47.3) | < 0.001 |
Non-hematologic toxicity, grade ≥ 3 | 101 (38.1) | 55 (32.0) | 46 (49.5) | 0.005 |
Treatment-related mortality | 22 (8.3) | 11 (6.4) | 11 (11.8) | 0.126 |
Dose reduction | 125 (47.2) | 69 (40.1) | 56 (60.2) | 0.002 |
Early treatment discontinuation | 47 (17.7) | 21 (12.2) | 26 (28.0) | 0.001 |