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Fig. 5 | BMC Cancer

Fig. 5

From: Characterization and comparison of human glioblastoma models

Fig. 5

Histopathological Analysis of Tumors in Mouse GBM Models Representative images of brain slices stained for luciferase (A, C, G) or E (B, D, H). A and B mice implanted with U87-luc2 (150,000) cells show large central tumors with little or no invasion. C, D, G, H U251-RedFLuc (1,000,000) tumors are small and linear (C and D) with invading tumor fronts and invasive cell nests (G and H). E Tumor invasiveness was determined with a subjective scoring method based on anti-luciferase IHC. F Tumor invasiveness determined with automatic cell counting based on anti-luciferase IHC. Statistics: Unpaired t-test (U251-RedFLuc vs. U87-luc2) **, p < 0.01; ***, p < 0.001 (Mean ± SEM; n = 5 mice/model)

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