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Table 3 Cox regression analysis of patients with NSCLC who received neoadjuvant therapy after IPTW

From: Evaluation of log odds of positive lymph nodes in predicting the survival of patients with non-small cell lung cancer treated with neoadjuvant therapy and surgery: a SEER cohort-based study

Variables

Univariable analysis

Multivariable analysis

HR (95%CI)

P

HR (95%CI)

P

LODDS

 LODDS<-1.07

Reference

 

Reference

 

 -1.07 ≤ LODDS<-0.27

1.445 (1.325-1.577)

< 0.001

1.437 (1.313-1.573)

< 0.001

 LODDS≥-0.27

2.318 (2.127-2.527)

< 0.001

2.459 (2.227-2.715)

< 0.001

Age

  ≤ 60 years old

Reference

 

Reference

 

 61-67 years old

1.282 (1.177-1.397)

< 0.001

1.360 (1.245-1.485)

< 0.001

  ≥ 68 years old

1.591 (1.471-1.721)

< 0.001

1.803 (1.659-1.959)

< 0.001

Gender

 Female

Reference

 

Reference

 

 Male

1.318 (1.231-1.411)

< 0.001

1.321 (1.227-1.422)

< 0.001

Race

 White

Reference

 

Reference

 

 Black

0.919 (0.814-1.037)

0.169

0.989 (0.874-1.119)

0.86

 Other

0.827 (0.723-0.946)

0.006

0.798 (0.694-0.917)

0.001

Marital status

 Married

Reference

 

Reference

 

 Unmarried

1.194 (1.078-1.324)

< 0.001

1.417 (1.272-1.578)

< 0.001

 Separated/Divorced/Widowed

1.064 (0.981-1.155)

0.135

1.163 (1.067-1.269)

< 0.001

Laterality

 Right

Reference

 

N/A

 

 Left

1.002 (0.935-1.073)

0.961

N/A

 

Primary site

 Main bronchus

Reference

 

Reference

 

 Upper lobe

1.068 (0.833-1.370)

0.603

1.109 (0.857-1.434)

0.432

 Middle lobe

1.130 (0.842-1.516)

0.416

1.265 (0.934-1.714)

0.128

 Lower lobe

1.293 (1.002-1.668)

0.048

1.373 (1.056-1.785)

0.018

 Overlapping lesion of lung

1.498 (1.079-2.078)

0.016

1.233 (0.885-1.719)

0.216

Histologic type

 Adenocarcinoma

Reference

 

Reference

 

 Squamous cell

1.111 (1.031-1.197)

0.006

1.022 (0.942-1.109)

0.598

 Other

0.982 (0.893-1.081)

0.716

0.911 (0.822-1.009)

0.073

Differentiation

 Grade I

Reference

 

Reference

 

 Grade II

1.254 (1.015-1.550)

0.036

1.223 (0.986-1.516)

0.067

 Grade III

1.361 (1.106-1.674)

0.004

1.258 (1.018-1.554)

0.034

 Grade IV

1.153 (0.843-1.577)

0.373

1.289 (0.936-1.776)

0.12

 Unknown

1.116 (0.899-1.386)

0.321

1.140 (0.913-1.423)

0.247

T

 T1

Reference

 

Reference

 

 T2

1.163 (1.038-1.302)

0.009

1.116 (0.993-1.253)

0.065

 T3

1.337 (1.196-1.494)

< 0.001

1.337 (1.194-1.497)

< 0.001

 T4

1.405 (1.253-1.575)

< 0.001

1.468 (1.302-1.656)

< 0.001

N

 N0

Reference

 

Reference

 

 N1

1.356 (1.219-1.508)

< 0.001

0.930 (0.829-1.043)

0.216

 N2

1.416 (1.299-1.544)

< 0.001

1.046 (0.947-1.156)

0.377

 N3

1.542 (1.231-1.931)

< 0.001

1.062 (0.840-1.342)

0.617

Surgery

 Sublobectomy

Reference

 

Reference

 

 Lobectomy

0.819 (0.687-0.977)

0.027

0.913 (0.762-1.093)

0.32

 Pneumonectomy

1.028 (0.851-1.241)

0.776

1.156 (0.949-1.408)

0.149

Radiotherapy

 No/Unknown

Reference

 

Reference

 

 Yes

1.065 (0.989-1.146)

0.096

1.067 (0.987-1.153)

0.105

Chemotherapy

 No/Unknown

Reference

 

N/A

 

 Yes

0.936 (0.692-1.266)

0.67

N/A

 
  1. NSCLC Non-small cell lung cancer, IPTW Inverse probability of treatment weighting, HR Hazard ratio, CI Confidence interval, LODDS Log odds of positive lymph nodes