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Table 2 Cox regression analysis of patients with NSCLC who received neoadjuvant therapy before IPTW

From: Evaluation of log odds of positive lymph nodes in predicting the survival of patients with non-small cell lung cancer treated with neoadjuvant therapy and surgery: a SEER cohort-based study

Variables

Univariable analysis

Multivariable analysis

HR (95%CI)

P

HR (95%CI)

P

LODDS

 LODDS<-1.07

Reference

 

Reference

 

 -1.07 ≤ LODDS<-0.27

1.387 (1.220-1.578)

< 0.001

1.396 (1.220-1.598)

< 0.001

 LODDS≥-0.27

2.026 (1.719-2.388)

< 0.001

2.116 (1.759-2.544)

< 0.001

Age

≤60 years old

Reference

 

Reference

 

 61-67 years old

1.300 (1.123-1.504)

< 0.001

1.353 (1.168-1.568)

< 0.001

  ≥ 68 years old

1.583 (1.385-1.808)

< 0.001

1.716 (1.497-1.967)

< 0.001

Gender

 Female

Reference

 

Reference

 

 Male

1.233 (1.098-1.384)

< 0.001

1.246 (1.107-1.401)

< 0.001

Race

 White

Reference

 

N/A

 

 Black

0.874 (0.715-1.069)

0.19

N/A

 

 Other

0.858 (0.685-1.075)

0.182

N/A

 

Marital status

 Married

Reference

 

N/A

 

 Unmarried

1.106 (0.929-1.316)

0.259

N/A

 

 Separated/Divorced/Widowed

1.064 (0.926-1.222)

0.383

N/A

 

Laterality

 Right

Reference

 

Reference

 

 Left

0.900 (0.800-1.012)

0.078

0.958 (0.848-1.083)

0.495

Primary site

 Main bronchus

Reference

 

Reference

 

 Upper lobe

1.105 (0.736-1.659)

0.631

0.968 (0.642-1.460)

0.876

 Middle lobe

1.436 (0.887-2.327)

0.141

1.204 (0.736-1.967)

0.46

 Lower lobe

1.423 (0.939-2.158)

0.096

1.223 (0.803-1.861)

0.348

 Overlapping lesion of lung

1.826 (1.083-3.079)

0.024

1.383 (0.814-2.348)

0.231

Histologic type

 Adenocarcinoma

Reference

 

N/A

 

 Squamous cell

0.986 (0.867-1.121)

0.825

N/A

 

 Other

0.935 (0.796-1.098)

0.411

N/A

 

Differentiation

 Grade I

Reference

 

Reference

 

 Grade II

1.266 (0.888-1.803)

0.192

1.229 (0.861-1.753)

0.256

 Grade III

1.403 (0.993-1.983)

0.055

1.358 (0.959-1.923)

0.085

 Grade IV

1.342 (0.834-2.160)

0.225

1.431 (0.886-2.310)

0.143

 Unknown

1.099 (0.764-1.580)

0.611

1.091 (0.757-1.574)

0.639

T

 T1

Reference

 

Reference

 

 T2

1.153 (0.954-1.392)

0.14

1.147 (0.948-1.389)

0.158

 T3

1.277 (1.061-1.537)

0.01

1.363 (1.128-1.647)

0.001

 T4

1.175 (0.969-1.424)

0.101

1.336 (1.094-1.632)

0.004

N

 N0

Reference

 

Reference

 

 N1

1.132 (0.951-1.348)

0.163

0.934 (0.778-1.120)

0.459

 N2

1.223 (1.069-1.398)

0.003

1.021 (0.878-1.186)

0.791

 N3

1.240 (0.819-1.877)

0.309

0.962 (0.631-1.468)

0.858

Surgery

 Sublobectomy

Reference

 

N/A

 

 Lobectomy

0.866 (0.648-1.159)

0.334

N/A

 

 Pneumonectomy

1.086 (0.796-1.482)

0.602

N/A

 

Radiotherapy

 No/Unknown

Reference

 

Reference

 

 Yes

1.173 (1.035-1.330)

0.013

1.203 (1.054-1.372)

0.006

Chemotherapy

 No/Unknown

Reference

 

N/A

 

 Yes

0.927 (0.619-1.389)

0.715

N/A

 
  1. NSCLC Non-small cell lung cancer, IPTW Inverse probability of treatment weighting, HR Hazard ratio, CI Confidence interval, LODDS Log odds of positive lymph nodes
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