Fig. 1
From: Genomic signature of MTOR could be an immunogenicity marker in human colorectal cancer
Expression analysis of MTOR in cancers. A The MTOR expression levels in 15 out of 33 categories of human cancers differed from normal tissues. *p < 0.05, **p < 0.01, ***p < 0.001. The blue boxes represent normal tissues; the red boxes represent tumor tissues; the purple boxes represent metastatic tumor tissues. ACC, Adrenocortical carcinoma; BLCA, Bladder urothelial carcinoma; BRCA, Breast invasive carcinoma; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, Cholangiocarcinoma; COAD, Colon adenocarcinoma; DLBC, Lymphoid neoplasm diffuse large b-cell lymphoma; ESCA, Esophageal carcinoma; GBM, Glioblastoma multiforme; HNSC, Head and neck squamous cell carcinoma; KICH, Kidney chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LAML, Acute myeloid leukemia; LGG, Brain lower grade glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MESO, Mesothelioma; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PCPG, Pheochromocytoma and paraganglioma; PRAD, Prostate adenocarcinoma; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin cutaneous melanoma; STAD, Stomach adenocarcinoma; TGCT, Testicular germ cell tumors; THCA, Thyroid carcinoma; THYM, Thymoma; UCEC, Uterine corpus endometrial carcinoma. UCS, Uterine carcinosarcoma; UVM, Uveal melanoma. B MTOR expression levels in CRC and corresponding normal tissues from TCGA. C Different MTOR expression levels between CRC and unpaired normal tissues from GSE41657. D Different MTOR expression levels between CRC and paired normal tissues from GSE113513. *p < 0.05. The GSE41657 and GSE113513 datasets are from Asian patients. E Representative immunohistochemistry (IHC) staining shows differences in mTOR expression between CRC and paired normal tissues from the Ruijin cohort. F The box plot displays the IHC scores for mTOR in CRC and paired normal tissues from the Ruijin cohort. CRC, colorectal cancer; TCGA, The Cancer Genome Atlas; mTOR, mammalian target of rapamycin