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Fig. 1 | BMC Cancer

Fig. 1

From: Neoadjuvant nivolumab + T-VEC combination therapy for resectable early stage or metastatic (IIIB-IVM1a) melanoma with injectable disease: study protocol of the NIVEC trial

Fig. 1

Study Schedule. Blood draw for PBMCs will be performed at screening, week 3, week 9 (prior to surgery), and first evaluation (week 12) and at moment of relapse. Tumor biopsies will be taken at screening, prior to first nivolumab administration and at moment of relapse in all patients for translational research purposes. Biopsies will be preserved and stored as fresh frozen and formalin-fixed paraffin-embedded material at all indicated time points. *The first dose of T-VEC is a seroconversion dose. CT, computed tomography; LDH, lactate dehydrogenase; MRI, magnetic resonance imaging; PBMC, peripheral blood mononuclear cells; PET, Positron Emission Tomography; PFU, plaque-forming units; QoL, quality of life questionnaires; RECIST, Response evaluation criteria in solid tumors; T-VEC, Talimogene laherparepvec; ULN, upper limit of normal; WHO PS, World Health Organization performance status

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BMC Cancer

ISSN: 1471-2407

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