Table 6 Dose modifications for panitumumab in case of CTCAE grade ≥ 3 skin or soft tissue toxicity
Occurrence of skin symptom(s): CTCAE grade ≥ 3 | Administration of panitumumab | Outcome | Dose regulation |
|---|---|---|---|
Initial occurrence | Withhold 1 or 2 doses | Improved (CTCAE grade < 3) | Continue at 100% of original dose (6 mg/kg) |
Not recovered | Discontinue panitumumab | ||
At the second occurence | Withhold 1 or 2 doses | Improved (CTCAE grade < 3) | Continue at 80% of original dose (4.8 mg/kg) |
Not recovered | Discontinue panitumumab | ||
At the third occurence | Withhold 1 or 2 doses | Improved (CTCAE grade < 3) | Continue at 60% of original dose (3.6 mg/kg) |
Not recovered | Discontinue panitumumab | ||
At the fourth occurence | Discontinue panitumumab |