Fig. 1

The estimation of the kidney function and calculation of the carboplatin doses in the current study. A Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) ²⁰⁰⁹ and CKD-EPI ²⁰²¹ are the most common formulae to calculate eGFR. Baseline patient characteristics, including patient age, bodyweight, sex, race, and SrCr, have different emphasis within each formula, resulting in different eGFR values for the same patient. B Once eGFR is calculated based on one of the equations, the Calvert formula is used to determine the appropriate carboplatin dose. C The research strategy is outlined