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Fig. 2 | BMC Cancer

Fig. 2

From: circ_0000045 promotes proliferation, migration, and invasion of head and neck squamous cell carcinomas via regulating HSP70 and MAPK pathway

Fig. 2

HNSCC cell proliferation, migration, and invasion inhibition through circ_0000045 silencing. A The relative expression of circ_0000045 and circ_0008386 in FaDu and SCC-9 cells after siRNA transfection. Expression of circ_0000045 was measured through qRT-PCR. B Alterations in SCC cell proliferation rates induced by silencing circ_0000045 and circ_0008386. C The decrease in FaDu cell proliferation rates caused by silencing circ_0000045’s expression. MTS method was performed to assess the proliferation rates of both FaDu and SCC-9 cells. D Inhibition of FaDu and SCC-9 cell invasion capacities caused by silenced circ_0000045 expression. Cell invasion was assessed using the Transwell system. E Changes in migration rates of FaDu and SCC-9 cells induced by the knockdown of circ_0000045’s expression. A wound-healing assay was used to evaluate the migration speeds of HNSCC cells. N = 3; CON: control; si: siRNA; NC: negative control of siRNA; OD490: absorbance at 490 nm; *P < 0.05; **P < 0.01

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