Fig. 4

Patients in the two clusters differed in mutation landscape. A Comparison of the TMB score between cluster 1 and cluster 2 (Wilcoxon test; the asterisks represent p values; **P < 0.01) B Comparison of mutation types between cluster 1 and cluster 2 (Wilcoxon test; the lines in the boxes represent medians, and the asterisks represent p values; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns P > 0.05.) C, D Waterfall plot depicting the mutated genes of patients in different clusters