From: Incidence trends of childhood central nervous system tumors in Finland 1990–2017
1990–2017 | 1990–1994 | 2001–2005 | 2013–2017 | ||||
---|---|---|---|---|---|---|---|
APC (95% CI) | N | ASR (95%) | N | ASR (95%) | N | ASR (95%) | |
Total | 0.8 (0.2, 1.4) | 201 | 4.12 (4.03, 4.21) | 195 | 4.25 (4.15, 4.34) | 216 | 4.81 (4.71, 4.91) |
Sex | |||||||
Boys | 0.9 (0.1, 1.8) | 105 | 4.20 (4.07, 4.32) | 117 | 4.99 (4.85, 5.14) | 117 | 5.09 (4.94, 5.24) |
Girls | 0.7 (−0.3, 1.7) | 96 | 4.04 (3.91, 4.17) | 78 | 3.47 (3.35, 3.60) | 99 | 4.52 (4.37, 4.66) |
Age group | |||||||
0–4 years | 0.4 (−0.8, 1.5) | 85 | 5.28 (4.16, 6.41) | 68 | 4.78 (3.65, 5.92) | 82 | 5.60 (4.39, 6.82) |
5–9 years | 1.0 (−0.4, 2.3) | 61 | 3.81 (2.86, 4.77) | 66 | 4.30 (3.26, 5.33) | 70 | 4.57 (3.50, 5.64) |
10–14 years | 1.1 (−0.3, 2.4) | 55 | 3.37 (2.48, 4.26) | 61 | 3.71 (2.78, 4.65) | 64 | 4.33 (3.27, 5.39) |
Tumor grade | |||||||
Grade I | 1.0 (0.1, 2.0) | 80 | 1.64 (1.59, 1.70) | 96 | 2.09 (2.02, 2.15) | 98 | 2.20 (2.13, 2.27) |
Grade II | −0.5 (−2.5, 1.5) | 41 | 0.85 (0.81, 0.89) | 27 | 0.59 (0.56, 0.63) | 26 | 0.57 (0.54, 0.61) |
Grade III | 2.6 (0.0, 5.3) | 13 | 0.27 (0.24, 0.29) | 20 | 0.44 (0.40, 0.47) | 25 | 0.55 (0.51, 0.58) |
Grade IV | 0.7 (−0.4, 1.8) | 48 | 0.97 (0.93, 1.02) | 42 | 0.91 (0.87, 0.96) | 45 | 1.00 (0.95, 1.04) |
Tumor location | |||||||
Supratentorial | −0.9 (−2.1, 0.4) | 65 | 1.33 (1.28, 1.38) | 74 | 1.61 (1.55, 1.67) | 50 | 1.11 (1.06, 1.16) |
Infratentorial | 0.4 (−0.8, 1.6) | 86 | 1.76 (1.70, 1.82) | 86 | 1.87 (1.81, 1.93) | 88 | 1.95 (1.89, 2.02) |
Cerebellum | 0.1 (−1.2, 1.4) | 59 | 1.20 (1.15, 1.25) | 59 | 1.28 (1.23, 1.33) | 55 | 1.22 (1.17, 1.27) |
Brain stem | 1.6 (−0.4, 3.7) | 26 | 0.54 (0.51, 0.57) | 26 | 0.57 (0.54, 0.61) | 32 | 0.71 (0.67, 0.75) |
Spinal cord | 1.0 (−1.3, 3.4) | 15 | 0.31 (0.29, 0.34) | 11 | 0.24 (0.22, 0.26) | 14 | 0.32 (0.29, 0.34) |
Unspecified | 2.5 (−2.5, 7.8) | 30 | 0.61 (0.58, 0.65) | 20 | 0.44 (0.41, 0.47) | 58 | 1.29 (1.24, 1.35) |
Histology | |||||||
Diffuse astrocytic tumors | −1.7 (−3.5, 0.1) | 44 | 0.91 (0.87, 0.95) | 33 | 0.72 (0.68, 0.76) | 23 | 0.52 (0.48, 0.55) |
Other astrocytic tumors | 0.6 (−0.6, 1.8) | 63 | 1.30 (1.25, 1.35) | 67 | 1.45 (1.40, 1.51) | 66 | 1.48 (1.42, 1.54) |
Pilocytic astrocytoma | 0.4 (−0.9, 1.7) | 56 | 1.15 (1.10, 1.20) | 63 | 1.37 (1.31, 1.42) | 58 | 1.30 (1.24, 1.35) |
Ependymal tumors | 1.9 (−0.5, 4.4) | 13 | 0.27 (0.25, 0.29) | 20 | 0.44 (0.41, 0.47) | 23 | 0.50 (0.47, 0.54) |
Neuronal/glial tumors | 1.4 (−1.3, 4.2) | 13 | 0.27 (0.24, 0.29) | 23 | 0.50 (0.47, 0.53) | 23 | 0.52 (0.48, 0.55) |
Embryonal tumors | 1.2 (−0.1, 2.6) | 34 | 0.68 (0.65, 0.72) | 27 | 0.59 (0.55, 0.62) | 39 | 0.86 (0.82, 0.90) |
Medulloblastoma | 1.6 (−0.4, 3.6) | 22 | 0.45 (0.42, 0.48) | 14 | 0.31 (0.28, 0.33) | 30 | 0.66 (0.62, 0.70) |
Other tumors | 1.5 (−0.0, 3.1) | 34 | 0.69 (0.65, 0.73) | 25 | 0.55 (0.51, 0.58) | 42 | 0.93 (0.89, 0.98) |