Fig. 6

Antitumor efficacy of CoG133-CAR T cells in xenograft mice bearing double-positive tumors. A Schematic representation of the in vivo mouse bioluminescence study. B The tumor-derived bioluminescence images of mice inoculated with Huh7 cells and treated with normal T and CoG133-CAR T cells. C Statistical analysis of the bioluminescence images in the ROI at each time point. Statistics are presented as the means ± SDs. n = 5 per group. § P < 0.001 vs. the normal T, mock T, CD133-CAR T and GPC3-CAR T groups. D Survival curve showed the survival time of Huh7 tumor bearing mice treated with different effector cells. The results were evaluated by the log-rank (Mantel-Cox) test. n = 5 per group. § P < 0.001 vs. the normal T, mock T, CD133-CAR T and GPC3-CAR T groups