Table 3 Multivariable Cox regression analyses of variables correlated with clinical outcomes on the patients with locally advanced rectal cancer

 Gender

0.035*

0.729 (0.543–0.978)

0.348

0.859 (0.626–1.180)

0.144

0.820 (0.628–1.070)

 Age

0.674

0.937 (0.693–1.267)

0.165

1.247 (0.913–1.702)

0.797

1.036 (0.792–1.355)

 cT stage

0.500

0.918 (0.715–1.178)

0.757

0.959 (0.733–1.254)

0.929

1.010 (0.806–1.266)

 cN stage

0.309

0.758 (0.445–1.292)

0.821

1.074 (0.580–1.986)

0.286

0.772 (0.480–1.242)

 Pretreatment CEA

0.072

1.265 (0.979–1.634)

0.076

1.284 (0.975–1.691)

0.110

1.208 (0.958–1.523)

 Type of radiation

0.673

1.073 (0.772–1.492)

0.836

0.962 (0.668–1.386)

0.849

0.970 (0.707–1.330)

 Concurrent chemotherapy

0.871

0.973 (0.695–1.361)

0.682

1.073 (0.765–1.506)

0.820

0.967 (0.724–1.291)

 Adjuvant chemotherapy

0.112

1.379 (0.927–2.052)

0.814

0.954 (0.641–1.418)

0.182

1.265 (0.896–1.786)

 pCR

0.796

1.119 (0.477–2.626)

0.003*

3.634 (1.532–8.623)

0.160

1.648 (0.820–3.312)

 ypT stage

< 0.001*

2.066 (1.598–2.670)

< 0.001*

1.902 (1.497–2.417)

< 0.001*

1.770 (1.431–2.188)

 ypN stage

< 0.001*

1.768 (1.439–2.172)

< 0.001*

2.048 (1.639–2.558)

< 0.001*

1.941 (1.615–2.331)

 RCRG

0.817

0.992 (0.923–1.066)

0.133

1.050 (0.985–1.120)

0.287

1.031 (0.975–1.091)

 Gender

0.414

0.854 (0.584–1.248)

0.923

1.021 (0.666–1.565)

0.510

0.893 (0.636–1.252)

 Age

0.856

1.036 (0.707–1.519)

0.029*

1.562 (1.047–2.330)

0.291

1.196 (0.858–1.668)

 cT stage

0.629

0.921 (0.660–1.285)

0.492

1.138 (0.787–1.643)

0.591

1.086 (0.804–1.466)

 cN stage

0.469

0.773 (0.385–1.551)

0.768

1.127 (0.508–2.500)

0.828

0.932 (0.494–1.758)

 Pretreatment CEA

0.011*

1.526 (1.101–2.116)

0.013*

1.578 (1.100–2.263)

0.013*

1.447 (1.081–1.937)

 Type of radiation

0.438

1.182 (0.775–1.802)

0.492

1.169 (0.749–1.825)

0.712

1.072 (0.743–1.546)

 Concurrent chemotherapy

0.855

0.964–0.651-1.429)

0.482

1.163 (0.764–1.769)

0.775

0.950 (0.670–1.348)

 Adjuvant chemotherapy

0.040*

1.771 (1.027–3.053)

0.919

1.027 (0.612–1.724)

0.194

1.338 (0.862–2.077)

 pCR

0.383

0.623 (0.215–1.804)

0.256

1.864 (0.636–5.466)

0.960

1.022 (0.443–2.359)

 ypT stage

0.001*

1.701 (1.240–2.334)

0.037*

1.430 (1.023–2.000)

0.005*

1.459 (1.121–1.899)

 ypN stage

< 0.001*

1.903 (1.457–2.487)

< 0.001*

2.253 (1.680–3.022)

< 0.001*

2.023 (1.594–2.566)

 RCRG

0.577

1.027 (0.935–1.129)

0.243

1.056 (0.964–1.157)

0.365

1.037 (0.959–1.122)