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Table 1 Clinicopathological characteristics of the patients according to the level of inflammatory indices

From: C-reactive protein/albumin ratio and Glasgow prognostic score are associated with prognosis and infiltration of Foxp3+ or CD3+ lymphocytes in colorectal liver metastasis

 

Low NLR

High NLR

 

Low PLR

High PLR

 

Low CAR

High CAR

 

GPS: 0

GPS: 1/2

 

N=58 (%)

N=59 (%)

P-value

N=58 (%)

N=59 (%)

P-value

N=58 (%)

N=59 (%)

P-value

N=104 (%)

N=13 (%)

P-value

Sex

  

0.017*

  

0.401

  

0.220

  

0.292

 Male

31 (53.4%)

44 (74.6%)

 

35 (60.3%)

40 (67.8%)

 

34 (58.6%)

41 (69.5%)

 

65 (62.5%)

10 (76.9%)

 

 Female

27 (46.6%)

15 (25.4%)

 

23 (39.7%)

19 (32.2%)

 

24 (41.4%)

18 (30.5%)

 

39 (37.5%)

3 (23.1%)

 

Age (median, range), years

66 (38-81)

66 (33-83)

0.595

65.5 (33-81)

67 (41-83)

0.754

68 (33-83)

64 (38-83)

0.196

65.5 (33-83)

70 (45-83)

0.146

BMI (median, IQR)

21.9 (20.1-23.5)

22.1 (20.3-25.6)

0.460

23.2 (20.5-24.8)

21.2 (19.6-24.2)

0.096

22.5 (20-23.9)

21.8 (20.4-25.5)

0.639

21.8 (20.1-24)

23.6 (21-25.8)

0.204

Primary tumor location

  

0.955

  

0.439

  

0.720

  

0.355

 Right sided

16 (27.6%)

16 (27.1%)

 

14 (24.1%)

18 (30.5%)

 

15 (25.9%)

17 (28.8%)

 

27 (26%)

5 (38.5%)

 

 Left sided

42 (72.4%)

43 (72.9%)

 

44 (75.9%)

41 (69.5%)

 

43 (74.1%)

42 (71.2%)

 

77 (74%)

8 (61.5%)

 

NAC

  

0.521

  

0.162

  

0.045*

  

0.457

 No

33 (56.9%)

37 (62.7%)

 

31 (53.4%)

39 (66.1%)

 

40 (69%)

30 (50.8%)

 

61 (58.7%)

9 (69.2%)

 

 Yes

25 (43.1%)

22 (37.3%)

 

27 (46.6%)

20 (33.9%)

 

18 (31%)

29 (49.2%)

 

43 (41.3%)

4 (30.8%)

 

Preoperative CEA (median, IQR)

8.8 (3.7-19.7)

12.5 (3.9-45.2)

0.089

8.8 (3.7-19.8)

12.3 (5.1-47.9)

0.055

8.8 (.6-28.3)

12.2 (4.5-34)

0.263

9.4 (3.9-26.4)

1.3 (3.7-174.9)

0.192

Onset

  

0.778

  

0.646

  

0.646

  

0.896

 Metachronous

27 (46.6%)

29 (49.2%)

 

29 (50%)

27 (45.8%)

 

29 (50%)

27 (45.8%)

 

50 (48.1%)

6 (46.2%)

 

 Synchronous

31 (53.4%)

30 (50.8%)

 

29 (50%)

32 (54.2%)

 

29 (50%)

32 (54.2%)

 

54 (51.9%)

7 (53.8%)

 

Metastatic tumor location

  

0.074

  

0.306

  

0.619

  

1.000

 Bilobar

27 (46.6%)

18 (30.5%)

 

25 (43.1%)

20 (33.9%)

 

21 (36.2%)

24 (40.7%)

 

40 (38.5%)

5 (38.5%)

 

 Hemilobar

31 (53.4%)

41 (69.5%)

 

33 (56.9%)

39 (66.1%)

 

37 (63.8%)

35 (59.3%))

 

64 (61.5%)

8 (61.5%)

 

Liver tumor diameter (median, IQR)

25 (17.8-39.3)

25 (20-53)

0.197

24 (15-34.3)

33 (22-60)

0.0011*

23 (16.8-32.3)

38 (22-61)

<.0001*

25 (20-40)

60 (21.5-87.5)

0.011*

Tumor number

  

0.408

  

0.648

  

0.408

  

0.556

 Solitary

29 (50%)

25 (42.4%)

 

28 (48.3%)

26 (44.1%)

 

29 (50%)

25 (42.4%)

 

47 (45.2%)

7 (53.8%)

 

 Multiple

29 (50%)

34 (57.6%)

 

30 (51.7%)

33 (55.9%)

 

29 (50%)

34 (57.6%)

 

57 (54.8%)

6 (46.2%)

 
  1. BMI body mass index, CAR C-reactive protein/albumin ratio, CEA carcinoembryonic antigen, IQR interquartile range, GPS Glasgow prognostic score, NAC neoadjuvant chemotherapy, NLR neutrophil/lymphocyte ratio, PLR platelet/lymphocyte ratio