Study | Samples (n) | Entities tested | SST subtypes | Type of antibody | Positivity (%) | Type of staining | Correlations with clinical data |
---|---|---|---|---|---|---|---|
Papotti et al. 2001 [13] | 51 | MTC | SST1–5 | rabbit polyclonal (self-generated) | SST1: 49%, SST2: 43%, SST3: 47%, SST4: 4%, SST5: 57% | cell membrane and cytoplasm | no correlations with age, sex, tumour size or stage, histological type or outcome |
Druckenthaner et al. 2007 [14] | 8 | 7 PTC, 1 FTC | SST2 | rabbit polyclonal (Gramsch) | 87% | cell membrane | – |
Pisarek et al. 2009 [15] | 4 | 2 PTC, 2 PDC | SST1–5 | rabbit polyclonal (Gramsch) | SST1: 88.8%, SST2: 44.4%, SST3: 55.5%, SST4: 11.2%, SST5: 33.3% | cell membrane and cytoplasm | – |
Müssig et al. 2012 [16] | 93 | 67 PTC, 26 FTC | SST1–5 | SST2: rabbit monoclonal (clone UMB1) (Abcam); SST1, SST3, SST4, SST5: rabbit polyclonal (Gramsch) | SST1: 29%, SST2: 19%, SST3: 19%, SST4: 25%, SST5: 15% | cytoplasm | SST2 expression associated with good prognosis |
Pazaitou-Panayiotou et al. 2012 [17] | 47 (TMA) | 38 PTC, 4 FTC, 2 ATC, 3 HTC | SST1–5 | rabbit polyclonal (self-generated) | SST1: 75%, SST2: 100%, SST3: 100%, SST4: 38%, SST5: 75% | cell membrane and cytoplasm | no correlations found with tumour size or any other clinicopathological parameters |
Woelfl et al. 2014 [18] | 87 | 52 PTC, 24 FTC, 6 MTC, 2 PDC, 3 ATC | SST2, SST5 | rabbit monoclonal (clones UMB1, UMB4) (Abcam) | SST2: 11.49%, SST5: 86.20% | cell membrane | SST5 expression associated with good prognosis |
Herac et al. 2016 [19] | 97 | MTC | SST2, SST5 | Rabbit monoclonal (clones UMB1; UMB4) (Abcam) | SST2: 66%, SST5: 37.5% | cell membrane and cytoplasm | SST2: positive correlation with presence of lymph node MTS, locally advanced stage, desmoplasia and Ki-67 index; SST5: positive correlation with locally advanced stage and desmoplasia |
Kendler et al. 2017 [20] | 42 | MTC | SST1, SST2, SST3, SST5 | rabbit monoclonal (clones UMB7, UMB1, UMB5, UMB4) (Abcam) | SST1: 45.2%, SST2: 28.6%, SST3: 81%, SST5: 54.8% | cell membrane and cytoplasm | positive correlation between SST1 expression and response to initial surgery |
de Vries et al. 2018 [21] | 114 (TMA) | MTC + 34 MTS | SST2 | rabbit monoclonal, clone unknown (Biotrend) | 50.9% of PT | cell membrane | positive correlation with overall survival; different expression in PT and MTS |
Carmona Matos et al. 2019 [22] | 97 (TMA) | 57 PTC, 28 FTC, 10 ATC, 2 PDC | SST2 | rabbit monoclonal, clone UMB1 (Abcam) | n/s | nuclear and cytoplasm | – |
Thakur et al. 2021 [23] | 84 (TMA) | 39 PTC, 19 FTC, 6 PDC, 4 HTC, 16 MTC | SST2 | rabbit polyclonal (ab9550) (Abcam) | SST2: 50% high expression | n/s | – |