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Table 2 Relationship between common genetic alterations and clinicopathological factors of patients with SBA

From: Genetic analysis of Japanese patients with small bowel adenocarcinoma using next-generation sequencing

  

TP53

KRAS

APC

PIK3CA

CTNNB1

 

No.

No. (%)

P

No. (%)

P

No. (%)

P

No. (%)

P

No. (%)

P

Site

 Duodenum

3

3 (100)

NS

0

NS

1 (33)

NS

0

NS

0

NS

 Jejunum

16

12 (75)

 

4 (25)

 

3 (19)

 

4 (25)

 

2 (13)

 

 Ileum

3

1 (33)

 

2 (67)

 

1 (33)

 

0

 

1 (33)

 

Histology

 Differntiated

15

12 (75)

NS

5 (33)

NS

5 (33)

NS

3 (20)

NS

1 (7)

NS

 Por

5

3 (60)

 

1 (20)

 

0

 

1 (20)

 

1 (20)

 

 Muc

2

1 (50)

 

0

 

0

 

0

 

1 (50)

 

mucin phenotype

 Gastric type

2

2 (100)

NS

0

NS

0

NS

1 (50)

NS

0

NS

 GI type

3

1 (33)

 

1 (33)

 

0

 

1 (33)

 

0

 

 Intestinal type

12

9 (75)

 

4 (33)

 

4 (33)

 

1 (8)

 

2 (17)

 

 Null type

5

4 (80)

 

1 (20)

 

1 (20)

 

1 (20)

 

1 (20)

 

pT

 pT1-3

20

15 (75)

NS

5 (25)

NS

3 (15)

0.043

4 (20)

NS

3 (15)

NS

 pT4

2

1 (50)

 

1 (50)

 

2 (100)

 

0

 

0

 

pN

 pN0

10

9 (90)

NS

1 (10)

NS

3 (30)

NS

3 (30)

NS

1 (10)

NS

 pNx

12

7 (58)

 

5 (42)

 

2 (17)

 

1 (8)

 

2 (17)

 

M factor

 negative

15

13 (87)

NS

4 (27)

NS

4 (27)

NS

3 (20)

NS

2 (13)

NS

 positive

7

3 (43)

 

2 (29)

 

1 (14)

 

1 (14)

 

1 (14)

 

TNM stage

 l

1

1 (100)

NS

0

NS

0

NS

0

NS

0

NS

 ll

9

8 (89)

 

1 (11)

 

3 (33)

 

3 (33)

 

1 (11)

 

 lll

5

4 (80)

 

3 (60)

 

1 (20)

 

0

 

1 (20)

 

 lV

7

3 (43)

 

2 (29)

 

1 (14)

 

1 (14)

 

1 (14)

 

MMR status

 pMMR

16

11 (69)

NS

4 (25)

NS

2 (13)

NS

2 (13)

NS

3 (19)

NS

 dMMR

6

5 (83)

 

2 (33)

 

3 (50)

 

2 (33)

 

0

 
  1. dMMR DNA mismatch repair-deficient, pMMR DNA mismatch repair-proficient